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dc.contributorConsorci Sanitari de Terrassa
dc.contributor.authorChatzikonstantinou, Thomas
dc.contributor.authorKapetanakis, Anargyros
dc.contributor.authorScarfo', Lydia
dc.contributor.authorAllsup, David
dc.contributor.authorCabrero, Alejandro Alonso
dc.contributor.authorCuéllar-García, C.
dc.contributor.authorKARAKATSOULIS, GEORGIOS
dc.date.accessioned2023-09-22T10:57:45Z
dc.date.available2023-09-22T10:57:45Z
dc.date.issued2021-12
dc.identifier.citationChatzikonstantinou T, Karakatsoulis G, Scarfò L, Karakatsoulis G, Allsup D, Cabrero AA, et al. COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study. Leukemia. 2021 Dec;35(12):3444-54.
dc.identifier.urihttps://hdl.handle.net/11351/10343
dc.descriptionChronic lymphocytic leukemia; Coronavirus infections; Mortality
dc.description.abstractPatients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.ispartofseriesLeukemia;35(12)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectLeucèmia limfoide
dc.subjectMortalitat
dc.subjectCOVID-19 (Malaltia)
dc.subject.meshCoronavirus Infections
dc.subject.meshLeukemia, Lymphoid
dc.subject.meshMortality
dc.titleCOVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41375-021-01450-8
dc.subject.decsinfecciones por Coronavirus
dc.subject.decsleucemia linfoide
dc.subject.decsmortalidad
dc.relation.publishversionhttps://doi.org/10.1038/s41375-021-01450-8
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.authoraffiliation[Chatzikonstantinou T] Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece. Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece. [Kapetanakis A] Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece. [Scarfò L] Università Vita-Salute San Raffaele and IRCC Ospedale San Raffaele, Milan, Italy. [Karakatsoulis G] Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece. Department of Mathematics, University of Ioannina, Ioannina, Greece. [Allsup D] Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, Hull, UK. [Cabrero AA] Spanish Society of Haematology and hemotherapy, Madrid, Spain. Hematology Department, Hospital Universitario de La Princesa, Madrid, Spain. [Cuéllar-García C] Unitat d'Hematologia, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain
dc.identifier.pmid34725454
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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