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ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by Dietary Lipotoxicity
(2021-03-05)
ARMCX3 is encoded by a member of the Armcx gene family and is known to be involved in nervous system development and function. We found that ARMCX3 is markedly upregulated in mouse liver in response to high lipid availability, ...
The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers
(2021-06-07)
The biology of breast cancer response to neoadjuvant therapy is underrepresented in the literature and provides a window-of-opportunity to explore the genomic and microenvironment modulation of tumours exposed to therapy. ...
The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy
(2021-04)
A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy with tacrolimus and rituximab is ...
The Role of Vascular Lesions in Diabetes Across a Spectrum of Clinical Kidney Disease
(2021-09)
Introduction
The clinical-histologic correlation in diabetic nephropathy is not completely known.
Methods
We analyzed nephrectomy specimens from 90 patients with diabetes and diverse degrees of proteinuria and glomerular ...
Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction
(2021-07)
In patients with a first anterior ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention, iron deficiency (ID) was associated with larger infarcts, more extensive microvascular ...
The Second Wind in McArdle Patients: Fitness Matters
(2021-10)
Background: The “second wind” (SW) phenomenon—commonly referring to both an initial period of marked intolerance to dynamic exercise (e.g., brisk walking) that is not followed by perceived improvement and disappearance of ...