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scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
(2024-03-20)
Background
Ineffective drug treatment is a major problem for many patients with immune-mediated inflammatory diseases (IMIDs). Important reasons are the lack of systematic solutions for drug prioritisation and repurposing ...
EoE CONNECT, the European Registry of Clinical, Environmental, and Genetic Determinants in Eosinophilic Esophagitis: rationale, design, and study protocol of a large-scale epidemiological study in Europe
(2022-02-02)
Background:
The growing prevalence of eosinophilic esophagitis (EoE) represents a considerable burden to patients and health care systems. Optimizing cost-effective management and identifying mechanisms for disease onset ...
Implantation of a double allogeneic human engineered tissue graft on damaged heart: insights from the PERISCOPE phase I clinical trial
(2024-04)
Background
In preclinical studies, the use of double allogeneic grafts has shown promising results in promoting tissue revascularization, reducing infarct size, preventing adverse remodelling and fibrosis, and ultimately ...
Genomic evolution of human respiratory syncytial virus during a decade (2013–2023): bridging the path to monoclonal antibody surveillance
(2024-05)
Objectives
This study investigated the prevalence, genetic diversity, and evolution of human respiratory syncytial virus (HRSV) in Barcelona from 2013 to 2023.
Methods
Respiratory specimens from patients with RTI suspicion ...
Cognitive Profile and Cardiovascular Risk Factors in Older Adults with Mild Cognitive Impairment
(2024-04-18)
The prevalence of cardiovascular risk factors (CVRFs) in the older adults population and their specific impact on their cognitive profiles still requires further research. For this purpose, a cross-sectional study was ...
Ultra Deep Sequencing of Circulating Cell-Free DNA as a Potential Tool for Hepatocellular Carcinoma Management
(2022-08-11)
Background: Cell-free DNA (cfDNA) concentrations have been described to be inversely correlated with prognosis in cancer. Mutations in HCC-associated driver genes in cfDNA have been reported, but their relation with patient’s ...
Standards of care and educational gaps in adult cystic fibrosis units: a European Respiratory Society survey
(2024-05-01)
Background Significant progress in the field of cystic fibrosis (CF) has substantially extended the life expectancy of patients with CF (pwCF). Consequently, the population of adult pwCF has outnumbered paediatric patients ...
Pan-European survey on current treatment strategies in patients with upfront resectable colorectal liver metastases
(2024-05)
Background
There is a lack of consensus on the definition of upfront resectability and use of perioperative systemic therapy for colorectal liver metastases (CRLM). This survey aimed to summarize the current treatment ...
Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
(2024-05-04)
Background
COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes ...
Early detection of accelerated aging and cellular decline (AACD): A consensus statement
(2021-04)
The cellular hallmarks of accelerated aging and their clinical expression may be grouped using the terms ‘accelerated aging and cellular decline’ (AACD) and/or ‘age-associated cellular decline’. This construct is designed ...