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How to Choose a Shunt for Patients with Normal Pressure Hydrocephalus: A Short Guide to Selecting the Best Shunt Assembly
(2021-03)
Most patients with hydrocephalus are still managed with the implantation of a cerebrospinal fluid (CSF) shunt in which the CSF flow is regulated by a differential-pressure valve (DPV). Our aim in this review is to discuss ...
MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
(2021-09-16)
Brain accumulation of amyloid-beta (Aβ) is a crucial feature in Alzheimer´s disease (AD) and cerebral amyloid angiopathy (CAA), although the pathophysiological relationship between these diseases remains unclear. Numerous ...
The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome
(2021-05-26)
KIF1A is a microtubule-dependent motor protein responsible for fast anterograde transport of synaptic vesicle precursors in neurons. Pathogenic variants in KIF1A have been associated with a wide spectrum of neurological ...
Stroke-induced immunosuppression: implications for the prevention and prediction of post-stroke infections
(2021-06-06)
Stroke produces a powerful inflammatory cascade in the brain, but also a suppression of the peripheral immune system, which is also called stroke-induced immunosuppression (SIIS). The main processes that lead to SIIS are ...
InterMiG: international differences in the therapeutic approach to migraine patients in specialized headache centers
(2021-05-24)
Background
There is currently a wide therapeutic arsenal for migraine patients, without a single first-line preventive drug and we choose the different available alternatives taking into account comorbidities, national ...
Use of Disease-Modifying Therapies in Pediatric Relapsing-Remitting Multiple Sclerosis in the United Kingdom
(2021-07)
Objectives To compare the real-world effectiveness of newer disease-modifying therapies (DMTs) vs injectables in children with relapsing-remitting multiple sclerosis (RRMS).
Methods In this retrospective, multicenter ...
Blood Biomarker Panels for the Early Prediction of Stroke‐Associated Complications
(2021-02)
Background
Acute decompensated heart failure (ADHF) and respiratory tract infections (RTIs) are potentially life‐threatening complications in patients experiencing stroke during hospitalization. We aimed to test whether ...
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
(2021-08)
Objective
Identifying common genetic variants that confer genetic risk for cluster headache.
Methods
We conducted a case–control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study ...
The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy
(2021-05)
While the elderly segment of the population continues growing in importance, neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition, exercise, and education, among others, influence ageing ...
Relevant factors for neurologists to define effectiveness of migraine preventive drugs and take decisions on treatment: my-LIFE European Delphi survey
(2021-11)
Background
Clinical guidelines agree that preventive treatment should be considered in patients with uncontrolled migraine despite acute medications or patients with ≥4 migraine days per month. However, the criteria to ...