Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications
dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Fernandes de Rafael, Diana |
dc.contributor.author | Da Silva Andrade, Fernanda Raquel |
dc.contributor.author | Martínez Trucharte, Francesc |
dc.contributor.author | Basas Satorras, Jana |
dc.contributor.author | Seras Franzoso, Joaquin |
dc.contributor.author | Perez Burgos, Marc |
dc.contributor.author | Blanco Grau, Albert |
dc.contributor.author | López Fernandez, Alba |
dc.contributor.author | Vélez Villa, Roberto |
dc.contributor.author | Abasolo Olaortua, Ibane |
dc.contributor.author | Aguirre Canyadell, Màrius |
dc.contributor.author | Gavaldà Santapau, Joan |
dc.contributor.author | Schwartz Navarro, Simon |
dc.contributor.author | Palau Gauthier, Marta |
dc.contributor.author | Gomis Rodriguez, Javier |
dc.date.accessioned | 2019-04-09T11:14:07Z |
dc.date.available | 2019-04-09T11:14:07Z |
dc.date.issued | 2019-03-06 |
dc.identifier.citation | Rafael D, Andrade F, Martinez-Trucharte F, Basas J, Seras-Franzoso J, Palau M, et al. Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications. Nanomaterials. 2019; 9(3):e380. |
dc.identifier.issn | 2079-4991 |
dc.identifier.uri | https://hdl.handle.net/11351/4032 |
dc.description | Anti-bacterial agents; Post-operative infections; Silver nanoparticles |
dc.description.abstract | Hydrogels (HG) have recognized benefits as drug delivery platforms for biomedical applications. Their high sensitivity to sterilization processes is however one of the greatest challenges regarding their clinical translation. Concerning infection diseases, prevention of post-operatory related infections is crucial to ensure appropriate patient recovery and good clinical outcomes. Silver nanoparticles (AgNPs) have shown good antimicrobial properties but sustained release at the right place is required. Thus, we produced and characterized thermo-sensitive HG based on Pluronic® F127 loaded with AgNPs (HG-AgNPs) and their integrity and functionality after sterilization by dry-heat and autoclave methods were carefully assessed. The quality attributes of HG-AgNPs were seriously affected by dry-heat methods but not by autoclaving methods, which allowed to ensure the required sterility. Also, direct sterilization of the final HG-AgNPs product proved more effective than of the raw material, allowing simpler production procedures in non-sterile conditions. The mechanical properties were assessed in post mortem rat models and the HG-AgNPs were tested for its antimicrobial properties in vitro using extremely drug-resistant (XDR) clinical strains. The produced HG-AgNPs prove to be versatile, easy produced and cost-effective products, with activity against XDR strains and an adequate gelation time and spreadability features and optimal for in situ biomedical applications. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Nanomaterials;9(3) |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source | Scientia |
dc.subject | Esterilització |
dc.subject | Infecció - Prevenció |
dc.subject | Col·loides |
dc.subject.mesh | Sterilization |
dc.subject.mesh | /methods |
dc.subject.mesh | Hydrogels |
dc.subject.mesh | Infection |
dc.subject.mesh | /prevention & control |
dc.title | Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/nano9030380 |
dc.subject.decs | esterilización |
dc.subject.decs | /métodos |
dc.subject.decs | hidrogeles |
dc.subject.decs | infección |
dc.subject.decs | /prevención & control |
dc.relation.publishversion | https://www.mdpi.com/2079-4991/9/3/380 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Rafael D] Grup Drug Delivery & Targeting (DDT), Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Networking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, Madrid, Spain. [Andrade F] Grup Drug Delivery & Targeting (DDT), Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. INEB-Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Porto, Portugal. [Martinez-Trucharte F] Grup Drug Delivery & Targeting (DDT), Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Basas J] Laboratori de Resistencia Antimicrobiana, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0003), Instituto de Salud Carlos III, Madrid, Spain. [Seras-Franzoso J] Grup Drug Delivery & Targeting (DDT), Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Palau M] Laboratori de Resistencia Antimicrobiana, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0003), Instituto de Salud Carlos III, Madrid, Spain. [Gomis X] Laboratori de Resistència Antimicrobiana, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Pérez-Burgos M] Grup Drug Delivery & Targeting (DDT), Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Blanco A] Servei de Cirurgia Ortopèdica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Grup en Enginyeria tissular musculoesquelètica, Vall d’Hebron Institut de Recerca, Barcelona, Spain. [López-Fernández A] Grup en Enginyeria tissular musculoesquelètica, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Vélez R] Servei de Cirurgia Ortopèdica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Grup en Enginyeria tissular musculoesquelètica, Vall d’Hebron Institut de Recerca, Barcelona, Spain. [Abasolo I] Grup Drug Delivery & Targeting (DDT), Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Networking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, Madrid, Spain. [Aguirre M] Servei de Cirugia Ortopedica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Gavaldà J] Laboratori de Resistencia Antimicrobiana, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0003), Instituto de Salud Carlos III, Madrid, Spain. [Schwartz S Jr] Grup Drug Delivery & Targeting (DDT), Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Networking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, Madrid, Spain. |
dc.identifier.pmid | 30845683 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |
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