dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Corominas, Héctor |
dc.contributor.author | Alegre de Miguel, Cayetano |
dc.contributor.author | Narváez, Javier |
dc.contributor.author | Fernández-Cid, Carlos Marras |
dc.contributor.author | Torrente-Segarra, Vicenc |
dc.contributor.author | Gómez, Manuel Rodríguez |
dc.date.accessioned | 2019-08-22T06:18:03Z |
dc.date.available | 2019-08-22T06:18:03Z |
dc.date.issued | 2019-06 |
dc.identifier.citation | Corominas H, Alegre C, Narváez J, Fernández-Cid CM, Torrente-Segarra V, Gómez MR, et al. Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab. Medicine (Baltimore). 2019;98(26):e15947. |
dc.identifier.issn | 0025-7974 |
dc.identifier.uri | https://hdl.handle.net/11351/4267 |
dc.description | Rheumatoid arthritis; Fatigue; Tocilizumab |
dc.description.abstract | To assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effect in fatigue and other clinical and psychological disease-related factors in patients with rheumatoid arthritis (RA) treated with TCZ.A 24-week, multicenter, prospective, observational study in patients with moderate to severe RA receiving TCZ after failure or intolerance to disease-modifying antirheumatic drugs or tumor necrosis factor-alpha was conducted.Of the 122 patients included, 85 were evaluable for effectiveness (85% female, 51.9 ± 12.5 years, disease duration 8.7 ± 7.4 years). Mean change in C-reactive protein level from baseline to week 12 was -11.2 ± 4.0 (P < .001). Mean Disease Activity Index score (DAS28) decreased from 5.5 ± 1.0 at baseline to 2.7 ± 1.3 (P < .001) at week 24. Mean change in Functional Assessment of Chronic Illness Therapy score was -5.4 ± 11.2 points at week 24. Multiple regression analysis showed that the improvement in DAS28, sleep, and depression explained 56% and 47% of fatigue variance at week 12 and 24, respectively.Tocilizumab is effective in reducing disease activity and results in a clinically significant improvement in fatigue, pain, swollen joint count, morning stiffness, sleepiness, depression, and DAS28; the last 3 were specifically identified as factors explaining fatigue variance with the use of TCZ in RA patients. |
dc.language.iso | eng |
dc.publisher | Lippincott, Williams & Wilkins |
dc.relation.ispartofseries | Medicine;98(26) |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source | Scientia |
dc.subject | Fatiga |
dc.subject | Anticossos monoclonals |
dc.subject | Artritis reumatoide - Tractament |
dc.subject.mesh | Arthritis, Rheumatoid |
dc.subject.mesh | Fatigue |
dc.subject.mesh | /therapy |
dc.subject.mesh | Antibodies, Monoclonal, Humanized |
dc.subject.mesh | /therapeutic use |
dc.title | Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1097/MD.0000000000015947 |
dc.subject.decs | artritis reumatoide |
dc.subject.decs | fatiga |
dc.subject.decs | /terapia |
dc.subject.decs | anticuerpos monoclonales humanizados |
dc.subject.decs | /uso terapéutico |
dc.relation.publishversion | https://journals.lww.com/md-journal/fulltext/2019/06280/Correlation_of_fatigue_with_other_disease_related.11.aspx |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Corominas H] Departament de Reumatologia, Hospital Sant Joan Despí Moises Broggi, Sant Joan Despí, Spain. [Alegre C] Servei de Reumatologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Narváez J] Departament de Reumatologia, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain. [Fernández-Cid CM] Department of Rheumatology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain. [Torrente-Segarra V] Departament de Reumatologia, Hospital General de l'Hospitalet, L'Hospitalet de Llobregat, Spain. [Gómez MR] Department of Rheumatology, Complejo Hospitalario Cristal Piñor, Ourense, Spain. |
dc.identifier.pmid | 31261500 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |