dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Argemi, Josepmaria |
dc.contributor.author | Latasa, Maria U. |
dc.contributor.author | Atkinson, Stephen R. |
dc.contributor.author | Blokhin, Ilya O. |
dc.contributor.author | Massey, Veronica |
dc.contributor.author | Gue, Joel P. |
dc.contributor.author | Altamirano Gómez, José |
dc.date.accessioned | 2020-02-12T12:52:44Z |
dc.date.available | 2020-02-12T12:52:44Z |
dc.date.issued | 2019-07-16 |
dc.identifier.citation | Argemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, et al. Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Nat Commun. 2019;10(1):3126. |
dc.identifier.issn | 2041-1723 |
dc.identifier.uri | https://hdl.handle.net/11351/4617 |
dc.description | Seqüenciació d’ARN en el fetge; TGFβ1; Controladors epigenètics |
dc.description.sponsorship | This work was mainly supported by NIH/NIAAA funded Consortia "Integrated approaches for identifying molecular targets in alcoholic hepatitis" InTEAM (U01AA021908) (R.B., P.M., P.S-B., I.R., J.Cbl). This work was supported in part by: NIH/NIAAA (R01AA023781), USA (C.W.); Hepacare Project, Fundacion La Caixa, Spain (M.A.A., C.B. and M.U.L); Fond national de la recherche scientifique (FNRS J.0146.17) and Fond de la recherche scientifique medicale (FRSM T.0217.18), Belgium (P.S.); NIH/NCATS (UH3TR000503) and EPA (STAR 83573601), USA (D.L.V. and L.A.T.); MRC, UK (MK/K001949/1) and NIH/NIAAA, USA (UO1AA018663) (J.M.); NIH/NIAAA (1U01AA021908-01-33490), Instituto de Salud Carlos III (PI17/00673) and Miguel Servet (CPII16/00041) and "Una manera de hacer Europa" program, European Regional Development Fund (ERDF), EU (P.S-B.); National Institute for Health Research Imperial Biomedical Research Centre and NIHR Health Technology Assessment Grant 08-14-44 (M.R.T.); NIH T32, DK007052, USA (L.R.E.); NIH/NIAAA (1U01AA021908) and AFEF (P.M., L.D., A. L.). |
dc.language.iso | eng |
dc.publisher | Nature Publishing Group |
dc.relation.ispartofseries | Nature Communications;10(1) |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source | Scientia |
dc.subject | Hepatitis |
dc.subject | Àcids nucleics - Anàlisi |
dc.subject | Epigenètica |
dc.subject.mesh | Hepatitis, Alcoholic |
dc.subject.mesh | Sequence Analysis, RNA |
dc.subject.mesh | Epigenesis, Genetic |
dc.title | Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1038/s41467-019-11004-3 |
dc.subject.decs | hepatitis alcohólica |
dc.subject.decs | análisis de secuencias de ARN |
dc.subject.decs | epigénesis genética |
dc.relation.publishversion | https://www.nature.com/articles/s41467-019-11004-3#Sec32 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.authoraffiliation | [Argemi J] Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, Pittsburgh, USA. University of Pittsburgh Medical Center (UPMC), Pittsburgh, USA. Liver Unit, Clínica Universidad de Navarra, Navarra, Pamplona. University of Navarra, Pamplona, Spain. [Latasa MU] Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. [Atkinson SR] Division of Digestive Diseases, Department of Surgery and Cancer, Imperial College London, London, UK. [Blokhin IO] Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, USA. [Massey V] Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, USA. [Gue JP] Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, Pittsburgh, USA. University of Pittsburgh Medical Center (UPMC), Pittsburgh, USA. [Altamirano J] Servei de Medicina Interna, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina Interna, Hospital Quiron Salud, Barcelona, Spain. |
dc.identifier.pmid | 31311938 |
dc.identifier.wos | 000475566800007 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |