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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorArgemi, Josepmaria
dc.contributor.authorLatasa, Maria U.
dc.contributor.authorAtkinson, Stephen R.
dc.contributor.authorBlokhin, Ilya O.
dc.contributor.authorMassey, Veronica
dc.contributor.authorGue, Joel P.
dc.contributor.authorAltamirano Gómez, José
dc.date.accessioned2020-02-12T12:52:44Z
dc.date.available2020-02-12T12:52:44Z
dc.date.issued2019-07-16
dc.identifier.citationArgemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, et al. Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Nat Commun. 2019;10(1):3126.
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/11351/4617
dc.descriptionSeqüenciació d’ARN en el fetge; TGFβ1; Controladors epigenètics
dc.description.sponsorshipThis work was mainly supported by NIH/NIAAA funded Consortia "Integrated approaches for identifying molecular targets in alcoholic hepatitis" InTEAM (U01AA021908) (R.B., P.M., P.S-B., I.R., J.Cbl). This work was supported in part by: NIH/NIAAA (R01AA023781), USA (C.W.); Hepacare Project, Fundacion La Caixa, Spain (M.A.A., C.B. and M.U.L); Fond national de la recherche scientifique (FNRS J.0146.17) and Fond de la recherche scientifique medicale (FRSM T.0217.18), Belgium (P.S.); NIH/NCATS (UH3TR000503) and EPA (STAR 83573601), USA (D.L.V. and L.A.T.); MRC, UK (MK/K001949/1) and NIH/NIAAA, USA (UO1AA018663) (J.M.); NIH/NIAAA (1U01AA021908-01-33490), Instituto de Salud Carlos III (PI17/00673) and Miguel Servet (CPII16/00041) and "Una manera de hacer Europa" program, European Regional Development Fund (ERDF), EU (P.S-B.); National Institute for Health Research Imperial Biomedical Research Centre and NIHR Health Technology Assessment Grant 08-14-44 (M.R.T.); NIH T32, DK007052, USA (L.R.E.); NIH/NIAAA (1U01AA021908) and AFEF (P.M., L.D., A. L.).
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesNature Communications;10(1)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectHepatitis
dc.subjectÀcids nucleics - Anàlisi
dc.subjectEpigenètica
dc.subject.meshHepatitis, Alcoholic
dc.subject.meshSequence Analysis, RNA
dc.subject.meshEpigenesis, Genetic
dc.titleDefective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41467-019-11004-3
dc.subject.decshepatitis alcohólica
dc.subject.decsanálisis de secuencias de ARN
dc.subject.decsepigénesis genética
dc.relation.publishversionhttps://www.nature.com/articles/s41467-019-11004-3#Sec32
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.authoraffiliation[Argemi J] Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, Pittsburgh, USA. University of Pittsburgh Medical Center (UPMC), Pittsburgh, USA. Liver Unit, Clínica Universidad de Navarra, Navarra, Pamplona. University of Navarra, Pamplona, Spain. [Latasa MU] Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. [Atkinson SR] Division of Digestive Diseases, Department of Surgery and Cancer, Imperial College London, London, UK. [Blokhin IO] Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, USA. [Massey V] Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, USA. [Gue JP] Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, Pittsburgh, USA. University of Pittsburgh Medical Center (UPMC), Pittsburgh, USA. [Altamirano J] Servei de Medicina Interna, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina Interna, Hospital Quiron Salud, Barcelona, Spain.
dc.identifier.pmid31311938
dc.identifier.wos000475566800007
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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