dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Avdeev, Sergey |
dc.contributor.author | Aisanov, Zaurbek |
dc.contributor.author | Arkhipov, Vladimir |
dc.contributor.author | Belevskiy, Andrey |
dc.contributor.author | Leshchenko, Igor |
dc.contributor.author | Ovcharenko, Svetlana |
dc.contributor.author | Miravitlles Fernández, Marc |
dc.date.accessioned | 2020-02-17T12:54:43Z |
dc.date.available | 2020-02-17T12:54:43Z |
dc.date.issued | 2019-06-10 |
dc.identifier.citation | Avdeev S, Aisanov Z, Arkhipov V, Belevskiy A, Leshchenko I, Ovcharenko S, et al. Withdrawal of inhaled corticosteroids in COPD patients: Rationale and algorithms. Int J Chron Obstruct Pulmon Dis. 2019;14:1267–80. |
dc.identifier.issn | 1178-2005 |
dc.identifier.uri | https://hdl.handle.net/11351/4643 |
dc.description | COPD; Treatment algorithm; Guideline adherence |
dc.description.abstract | Observational studies indicate that overutilization of inhaled corticosteroids (ICS) is common in patients with chronic obstructive pulmonary disease (COPD). Overprescription and the high risk of serious ICS-related adverse events make withdrawal of this treatment necessary in patients for whom the treatment-related risks outweigh the expected benefits. Elaboration of an optimal, universal, user-friendly algorithm for withdrawal of ICS therapy has been identified as an important clinical need. This article reviews the available evidence on the efficacy, risks, and indications of ICS in COPD, as well as the benefits of ICS treatment withdrawal in patients for whom its use is not recommended by current guidelines. After discussing proposed approaches to ICS withdrawal published by professional associations and individual authors, we present a new algorithm developed by consensus of an international group of experts in the field of COPD. This relatively simple algorithm is based on consideration and integrated assessment of the most relevant factors (markers) influencing decision-making, such a history of exacerbations, peripheral blood eosinophil count, presence of infection, and risk of community-acquired pneumonia. |
dc.language.iso | eng |
dc.publisher | Dovepress |
dc.relation.ispartofseries | International Journal of Chronic Obstructive Pulmonary Disease;14 |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source | Scientia |
dc.subject | Pulmons - Malalties obstructives |
dc.subject | Corticosteroides |
dc.subject | Teràpia respiratòria |
dc.subject.mesh | Pulmonary Disease, Chronic Obstructive |
dc.subject.mesh | Adrenal Cortex Hormones |
dc.subject.mesh | Administration, Inhalation |
dc.title | Withdrawal of inhaled corticosteroids in COPD patients: rationale and algorithms |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.2147/COPD.S207775 |
dc.subject.decs | enfermedad pulmonar obstructiva crónica |
dc.subject.decs | hormonas de la corteza suprarrenal |
dc.subject.decs | administración por inhalación |
dc.relation.publishversion | https://www.dovepress.com/withdrawal-of-inhaled-corticosteroids-in-copd-patients-rationale-and-a-peer-reviewed-article-COPD |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.authoraffiliation | [Avdeev S] Department of Pulmonology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation. Clinical Department, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia, Moscow, Russian Federation. [Aisanov Z, Belevskiy A] Department of Pulmonology, N.I. Pirogov Russian State National Research Medical University, Moscow, Russian Federation. [Arkhipov V] Department of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation. [Leshchenko I] Department of Phthisiology, Pulmonology and Thoracic Surgery, Ural State Medical University, Ekaterinburg, Russian Federation. [Ovcharenko S] Department of Internal Diseases No.1, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation. [Miravitlles M] Servei de Pneumologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de investigación en red de enfermedades respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII) Madrid, Spain. |
dc.identifier.pmid | 31354256 |
dc.identifier.wos | 000471623600001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |