dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Balk, Lisanne J |
dc.contributor.author | Coric, Danko |
dc.contributor.author | Knier, Benjamin |
dc.contributor.author | Zimmermann, Hanna G |
dc.contributor.author | Behbehani, Raed |
dc.contributor.author | Alroughani, Raed |
dc.contributor.author | Vidal Jordana, Angela |
dc.contributor.author | Montalban Gairín, Xavier |
dc.date.accessioned | 2020-07-02T11:12:24Z |
dc.date.available | 2020-07-02T11:12:24Z |
dc.date.issued | 2019-09-05 |
dc.identifier.citation | Balk LJ, Coric D, Knier B, Zimmermann HG, Behbehani R, Alroughani R, et al. Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT study. Mult Scler J - Exp Transl Clin. 2019;5(3). |
dc.identifier.issn | 2055-2173 |
dc.identifier.uri | https://hdl.handle.net/11351/5056 |
dc.description | Inner nuclear layer; Multiple sclerosis; Optical coherence tomography |
dc.description.abstract | Background: The association of peripapillary retinal nerve fibre layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness with neurodegeneration in multiple sclerosis (MS) is well established. The relationship of the adjoining inner nuclear layer (INL) with inflammatory disease activity is less well understood. Objective: The objective of this paper is to investigate the relationship of INL volume changes with inflammatory disease activity in MS. Methods In this longitudinal, multi-centre study, optical coherence tomography (OCT) and clinical data (disability status, relapses and MS optic neuritis (MSON)) were collected in 785 patients with MS (68.3% female) and 92 healthy controls (63.4% female) from 11 MS centres between 2010 and 2017 and pooled retrospectively. Data on pRNFL, GCIPL and INL were obtained at each centre. Results: There was a significant increase in INL volume in eyes with new MSON during the study (N=61/1562, β=0.01mm3, p<.001). Clinical relapses (other than MSON) were significantly associated with increased INL volume (β=0.005, p=.025). INL volume was independent of disease progression (β=0.002mm3, p=.474). Conclusion: Our data demonstrate that an increase in INL volume is associated with MSON and the occurrence of clinical relapses. Therefore, INL volume changes may be useful as an outcome marker for inflammatory disease activity in MSON and MS treatment trials. |
dc.language.iso | eng |
dc.publisher | SAGE Publications |
dc.relation.ispartofseries | Multiple Sclerosis Journal - Experimental, Translational and Clinical;5(3) |
dc.rights | Attribution-NonCommercial 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ |
dc.source | Scientia |
dc.subject | Esclerosi múltiple |
dc.subject | Ulls - Tomografia |
dc.subject | Retina |
dc.subject.mesh | Multiple Sclerosis |
dc.subject.mesh | Tomography, Optical Coherence |
dc.subject.mesh | Retina |
dc.title | Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT study |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1177/2055217319871582 |
dc.subject.decs | esclerosis múltiple |
dc.subject.decs | tomografía de coherencia óptica |
dc.subject.decs | retina |
dc.relation.publishversion | https://journals.sagepub.com/doi/10.1177/2055217319871582 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.authoraffiliation | [Balk LJ, Coric D] Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. [Knier B] Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Germany. [Zimmermann HG] Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany. [Behbehani R] Al-Bahar Ophthalmology Centre, Ibn Sina Hospital, Kuwait. [Alroughani R] Division of Neurology, Department of Medicine, Amiri Hospital, Kuwait. [Vidal-Jordana A] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Servei de Neuroimmunologia Clínica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Montalban X] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Servei de Neuroimmunologia Clínica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Canada |
dc.identifier.pmid | 31523449 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |