dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Ramos-Araque, María E. |
dc.contributor.author | Siegler, James E. |
dc.contributor.author | Ribó Jacobi, Marc |
dc.contributor.author | Requena Ruiz, Manuel |
dc.contributor.author | López, Cristina |
dc.contributor.author | de Lera, Mercedes |
dc.date.accessioned | 2021-06-11T06:36:54Z |
dc.date.available | 2021-06-11T06:36:54Z |
dc.date.issued | 2021-01-30 |
dc.identifier.citation | Ramos-Araque ME, Siegler JE, Ribo M, Requena M, López C, de Lera M, et al. Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry. BMC Neurol. 2021 Jan 30;21:43. |
dc.identifier.issn | 1471-2377 |
dc.identifier.uri | https://hdl.handle.net/11351/6051 |
dc.description | Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Stroke; Mortality |
dc.description.abstract | Background and purpose Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology. Methods We explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18 years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20–6/16/20). Results Of the 14.483 laboratory-confirmed patients with COVID-19, 156 (1.1%) were diagnosed with AIS. Sixty-one (39.4%) were female, 84 (67.2%) white, and 88 (61.5%) were between 60 and 79 years of age. The most frequently reported etiology of AIS was cryptogenic (55/129, 42.6%), which was associated with significantly higher white blood cell count, c-reactive protein, and D-dimer levels than non-cryptogenic AIS patients (p</=0.05 for all comparisons). In a multivariable backward stepwise regression model estimating the odds of in-hospital mortality, cryptogenic stroke mechanism was associated with a fivefold greater odds in-hospital mortality than strokes due to any other mechanism (adjusted OR 5.16, 95%CI 1.41–18.87, p = 0.01). In that model, older age (aOR 2.05 per decade, 95%CI 1.35–3.11, p < 0.01) and higher baseline NIHSS (aOR 1.12, 95%CI 1.02–1.21, p = 0.01) were also independently predictive of mortality. Conclusions Our findings suggest that cryptogenic stroke among COVID-19 patients carries a significant risk of early mortality. |
dc.language.iso | eng |
dc.publisher | BMC |
dc.relation.ispartofseries | BMC Neurology;21 |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Isquèmia cerebral - Mortalitat |
dc.subject | Malalties - Factors de risc |
dc.subject | COVID-19 (Malaltia) |
dc.subject.mesh | Brain Ischemia |
dc.subject.mesh | /mortality |
dc.subject.mesh | Risk Factors |
dc.subject.mesh | Coronavirus Infections |
dc.title | Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1186/s12883-021-02075-1 |
dc.subject.decs | isquemia cerebral |
dc.subject.decs | /mortalidad |
dc.subject.decs | factores de riesgo |
dc.subject.decs | infecciones por Coronavirus |
dc.relation.publishversion | https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-021-02075-1 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Ramos-Araque ME] Institute of Biomedical Research of Salamanca, Department of Neurology, Hospital Universitario de Salamanca, Salamanca, Spain. Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain. [Siegler JE] Cooper Neurologic Institute, Cooper University Hospital, Camden, NJ, USA. [Ribo M, Requena M] Unitat d’Ictus, Servei de Neurologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [López C, de Lera M] Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain |
dc.identifier.pmid | 33514335 |
dc.identifier.wos | 000616461000001 |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/PE2017-2020/JR19%2F00020 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |