dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Notararigo, Sara |
dc.contributor.author | Otal Navarro, Anna |
dc.contributor.author | Cristobo, Iván |
dc.contributor.author | Antolín Mate, María |
dc.contributor.author | Guarner Aguilar, Francisco |
dc.contributor.author | Varela Castro, Encarna |
dc.date.accessioned | 2021-06-14T12:31:32Z |
dc.date.available | 2021-06-14T12:31:32Z |
dc.date.issued | 2021-02-05 |
dc.identifier.citation | Notararigo S, Varela E, Otal A, Cristobo I, Antolín M, Guarner F, et al. Evaluation of an O2-Substituted (1–3)-β-D-Glucan, Produced by Pediococcus parvulus 2.6, in ex vivo Models of Crohn’s Disease. Front Microbiol. 2021 Feb 5;12:621280. |
dc.identifier.issn | 1664-302X |
dc.identifier.uri | https://hdl.handle.net/11351/6068 |
dc.description | Crohn's disease anti-inflammatory effect; Immunomodulation; Bacterial exopolysaccharides |
dc.description.abstract | 1,3-β-glucans are extracellular polysaccharides synthesized by microorganisms and plants, with therapeutic potential. Among them, the O2-substituted-(1–3)-β-D-glucan, synthesized by some lactic acid bacteria (LAB), has a prebiotic effect on probiotic strains, an immunomodulatory effect on monocyte-derived macrophages, and potentiates the ability of the producer strain to adhere to Caco-2 cells differentiated to enterocytes. In this work, the O2-substituted-(1–3)-β-D-glucan polymers produced by GTF glycoyltransferase in the natural host Pediococcus parvulus 2.6 and in the recombinant strain Lactococcus lactis NZ9000[pNGTF] were tested. Their immunomodulatory activity was investigated in an ex vivo model using human biopsies from patients affected by Crohn’s disease (CD). Both polymers had an anti-inflammatory effect including, a reduction of Interleukine 8 both at the level of its gene expression and its secreted levels. The overall data indicate that the O2-substituted-(1–3)-β-D-glucan have a potential role in ameliorating inflammation via the gut immune system cell modulation. |
dc.language.iso | eng |
dc.publisher | Frontiers Media |
dc.relation.ispartofseries | Frontiers in Microbiology;12 |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Crohn, Malaltia de |
dc.subject | Polisacàrids |
dc.subject | Lactobacil·làcies |
dc.subject.mesh | Pediococcus |
dc.subject.mesh | Crohn Disease |
dc.subject.mesh | beta-Glucans |
dc.title | Evaluation of an O2-Substituted (1–3)-β-D-Glucan, Produced by Pediococcus parvulus 2.6, in ex vivo Models of Crohn’s Disease |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3389/fmicb.2021.621280 |
dc.subject.decs | Pediococcus |
dc.subject.decs | enfermedad de Crohn |
dc.subject.decs | beta-glucanos |
dc.relation.publishversion | https://www.frontiersin.org/articles/10.3389/fmicb.2021.621280/full |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Notararigo S] Department of Microbial: and Plant Biotechnology, Margarita Salas Biological Research Centre (CIB-Margarita Salas-CSIC), Madrid, Spain. Department of Gastroenterology, Digestive System Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Foundation Health Research Institute of Santiago de Compostela (FIDIS), Santiago de Compostela, Spain. [Varela E] Department of Gastroenterology, Digestive System Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERehd, Instituto de Salud Carlos III, Madrid, Spain. [Otal A, Antolín M, Guarner F] Department of Gastroenterology, Digestive System Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Cristobo I] Department of Microbial: and Plant Biotechnology, Margarita Salas Biological Research Centre (CIB-Margarita Salas-CSIC), Madrid, Spain |
dc.identifier.pmid | 33613490 |
dc.identifier.wos | 000619456100001 |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/PE2017-2020/RTI2018-097114-B-I00 |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/1PN/2008-2011/PI12%2F00263 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |