dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Moreno, Gerard |
dc.contributor.author | Rodríguez, Alejandro |
dc.contributor.author | Sole Violan, Jordi |
dc.contributor.author | Martin-Loeches, Ignacio |
dc.contributor.author | Díaz, Emili |
dc.contributor.author | Bodí, María |
dc.contributor.author | Papiol Gallofré, Elisabeth |
dc.date.accessioned | 2021-06-15T12:56:49Z |
dc.date.available | 2021-06-15T12:56:49Z |
dc.date.issued | 2021-03-08 |
dc.identifier.citation | Moreno G, Rodríguez A, Sole-Violán J, Martín-Loeches I, Díaz E, Bodí M, et al. Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia. ERJ Open Res. 2021 Mar 8;7(1):00888-2020. |
dc.identifier.issn | 2312-0541 |
dc.identifier.uri | https://hdl.handle.net/11351/6077 |
dc.description | Respiratory infections and tuberculosis; Pulmonary pharmacology and therapeutics; Acute lung injury and critical care |
dc.description.abstract | Background The relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed. This study aimed to investigate the association between early oseltamivir treatment and ICU mortality in critically ill patients with influenza pneumonia.
Methods This was an observational study of patients with influenza pneumonia admitted to 184 ICUs in Spain during 2009–2018. The primary outcome was to evaluate the association between early oseltamivir treatment and ICU mortality compared with later treatment. Secondary outcomes were to compare the duration of mechanical ventilation and ICU length of stay between the early and later oseltamivir treatment groups. To reduce biases related to observational studies, propensity score matching and a competing risk analysis were performed.
Results During the study period, 2124 patients met the inclusion criteria. All patients had influenza pneumonia and received oseltamivir before ICU admission. Of these, 529 (24.9%) received early oseltamivir treatment. In the multivariate analysis, early treatment was associated with reduced ICU mortality (OR 0.69, 95% CI 0.51–0.95). After propensity score matching, early oseltamivir treatment was associated with improved survival rates in the Cox regression (hazard ratio 0.77, 95% CI 0.61–0.99) and competing risk (subdistribution hazard ratio 0.67, 95% CI 0.53–0.85) analyses. The ICU length of stay and duration of mechanical ventilation were shorter in patients receiving early treatment.
Conclusions Early oseltamivir treatment is associated with improved survival rates in critically ill patients with influenza pneumonia, and may decrease ICU length of stay and mechanical ventilation duration. |
dc.language.iso | eng |
dc.publisher | European Respiratory Society |
dc.relation.ispartofseries | ERJ Open Research;7(1) |
dc.rights | Attribution-NonCommercial 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ |
dc.source | Scientia |
dc.subject | Pneumònia vírica |
dc.subject | Medicaments antivírics |
dc.subject | Supervivència |
dc.subject.mesh | Pneumonia |
dc.subject.mesh | /drug therapy |
dc.subject.mesh | Survival Rate |
dc.title | Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1183/23120541.00888-2020 |
dc.subject.decs | tasa de supervivencia |
dc.subject.decs | neumonía |
dc.subject.decs | /farmacoterapia |
dc.relation.publishversion | https://openres.ersjournals.com/content/7/1/00888-2020 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Moreno G, Rodríguez A, Bodí M] Critical Care Dept, Hospital Universitari de Tarragona Joan XXIII, URV/IISPV/CIBERES, Tarragona, Spain. [Sole-Violán J] Critical Care Dept, Hospital Universitario de Gran Canaria Dr Negrín, CIBERES, Las Palmas de Gran Canaria, Spain. [Martín-Loeches I] Dept of Anaesthesia and Critical Care, St James’s University Hospital, Trinity Centre for Health Sciences, Multidisciplinary Intensive Care Research Organisation (MICRO), Dublin, Ireland. [Díaz E] Critical Care Dept, Hospital Parc Taulí, CIBERES, Sabadell, Spain. [Papiol E] Unitat de Cures Intensives (UCI), Vall d’Hebron Hospital Universitari, Barcelona, Spain |
dc.identifier.pmid | 33718494 |
dc.identifier.wos | 000642370600050 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |