dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Garralda Cabanas, Elena |
dc.contributor.author | Aguilar, Susana |
dc.contributor.author | Sala De Vedruna, Gemma |
dc.contributor.author | Viaplana Donato, Cristina |
dc.contributor.author | González-Zorelle, Jenifer |
dc.contributor.author | Grazia LoGiacco, Deborah |
dc.contributor.author | Ogbah, Zighereda |
dc.contributor.author | Mancuso, Francesco Mattia |
dc.contributor.author | Fasani, Roberta |
dc.contributor.author | Jiménez Flores, José Antonio |
dc.contributor.author | Martinez, Paola |
dc.contributor.author | Oaknin Benzaquen, Ana Mazaltob |
dc.contributor.author | Antunes de Melo Oliveira, Ana Mafalda |
dc.contributor.author | Balmaña Gelpí, Judith |
dc.contributor.author | Carles Galceran, Joan |
dc.contributor.author | Macarulla Mercadé, Teresa |
dc.contributor.author | Elez Fernandez, Mª Elena |
dc.contributor.author | Alsina Maqueda, Maria |
dc.contributor.author | Braña Garcia, Irene |
dc.contributor.author | Felip Font, Enriqueta |
dc.contributor.author | Tabernero Caturla, Josep |
dc.contributor.author | Rodon Ahnert, Jordi |
dc.contributor.author | Nuciforo, Paolo Giovanni |
dc.contributor.author | Vivancos Prellezo, Ana |
dc.contributor.author | Ramos Masdeu, Laia |
dc.contributor.author | Saura Manich, Cristina |
dc.contributor.author | Ruiz Pace, Fiorella |
dc.contributor.author | Dienstmann, Rodrigo |
dc.date.accessioned | 2021-11-04T07:05:25Z |
dc.date.available | 2021-11-04T07:05:25Z |
dc.date.issued | 2020-05-14 |
dc.identifier.citation | Dienstmann R, Garralda E, Aguilar S, Sala G, Viaplana C, Ruiz-Pace F, et al. Evolving Landscape of Molecular Prescreening Strategies for Oncology Early Clinical Trials. JCO Precis Oncol. 2020 May 14;4:505–13. |
dc.identifier.issn | 2473-4284 |
dc.identifier.uri | https://hdl.handle.net/11351/6495 |
dc.description | Precision oncology; Clinical Trials; Molecular prescreening |
dc.description.abstract | Most academic precision oncology programs have been designed to facilitate enrollment of patients in early clinical trials with matched targeted agents. Over the last decade, major changes were seen both in the targetable molecular alteration landscape and in drug development trends. In this article, we describe how the Vall d’Hebron Institute of Oncology molecular prescreening program adapted to a dynamic model of biomarker-drug codevelopment. We started with a tumor-agnostic hotspot mutation panel plus in situ hybridization and immunohistochemistry of selected markers and subsequently transitioned to tumor-specific amplicon-based next-generation sequencing (NGS) tests together with custom copy number, fusion, and outlier gene expression panels. All assays are optimized for archived formalin-fixed paraffin-embedded tumor tissues without matched germline sequencing. In parallel, biomarker-matched trials evolved from a scenario of few targets and large populations (such as PI3K inhibitors in PIK3CA mutants) to a complex situation with many targets and small populations (such as multiple targetable fusion events). Recruitment rates in clinical trials with mandatory biomarkers decreased over the last 3 years. Molecular tumor board meetings proved critical to guide oncologists on emerging biomarkers for clinical testing and interpretation of NGS results. The substantial increase of immunotherapy trials had a major impact in target prioritization and guided clinical implementation of new markers, such as tumor mutational burden, with larger exon-based NGS assays and gene expression signatures to capture microenvironment infiltration patterns. This new multiomics era of precision oncology is expected to increase the opportunities for early clinical trial matching. |
dc.language.iso | eng |
dc.publisher | American Society of Clinical Oncology |
dc.relation.ispartofseries | JCO Precision Oncology;4 |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source | Scientia |
dc.subject | Càncer - Immunoteràpia |
dc.subject | Càncer - Detecció precoç |
dc.subject.mesh | Neoplasms |
dc.subject.mesh | Immunotherapy |
dc.subject.mesh | Early Detection of Cancer |
dc.title | Evolving Landscape of Molecular Prescreening Strategies for Oncology Early Clinical Trials |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1200/PO.19.00398 |
dc.subject.decs | neoplasias |
dc.subject.decs | inmunoterapia |
dc.subject.decs | detección precoz del cáncer |
dc.relation.publishversion | https://doi.org/10.1200/PO.19.00398 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Dienstmann R, Aguilar S, Viaplana C, Ruiz-Pace F] Oncology Data Science, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Garralda E, Sala G, Oaknin A, Saura C, Oliveira M, Balmaña J, Carles J, Macarulla T, Elez E, Alsina M, Braña I, Felip E, Tabernero J] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [González-Zorelle J] Oncology Data Science, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. Cancer Genomics Lab, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Grazia LoGiacco D, Ogbah Z, Ramos Masdeu L, Mancuso F, Vivancos A] Cancer Genomics Lab, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Fasani R, Jimenez J, Martinez P, Nuciforo P] Molecular Oncology Lab, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Rodon J] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX |
dc.identifier.pmid | 32923891 |
dc.identifier.wos | 000538154100001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |