dc.contributor | IDIAP Jordi Gol |
dc.contributor.author | Llor, Carla |
dc.contributor.author | Garcia-Sangenis, Ana |
dc.contributor.author | Bjerrum, Lars |
dc.contributor.author | Morros, Rosa |
dc.contributor.author | Giner-Soriano, Maria |
dc.contributor.author | Ouchi, Dan |
dc.date.accessioned | 2021-11-12T08:42:23Z |
dc.date.available | 2021-11-12T08:42:23Z |
dc.date.issued | 2021-11-08 |
dc.identifier.citation | Llor C, Ouchi D, Giner-Soriano M, García-Sangenís A, Bjerrum L, Morros R. Correlation between previous antibiotic exposure and COVID-19 severity: a population-based cohort study. Antibiotics. 2021 Nov 8;10(11):1364. |
dc.identifier.issn | 2079-6382 |
dc.identifier.uri | https://hdl.handle.net/11351/6534 |
dc.description | Drug resistance; Primary health care; COVID-19; Anti-bacterial agents |
dc.description.abstract | We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 146,656 of whom were exposed to at least one antibiotic course (52.3%) during the preceding two years. A total of 25,222 presented severe COVID-19 infection (9%), and the risk of severity was highest among those exposed to antibiotics (OR 1.12; 95% CI: 1.04–1.21). Among all individuals exposed to antibiotics, high, recent and exposure to HPCIAs were correlated with increased COVID severity (OR 1.19; 95% CI: 1.14–1.26; 1.41; 95% CI: 1.36–1.46; and 1.35; 95% CI: 1.30–1.40, respectively). Our findings confirm a significant correlation between previous antibiotic exposure and increased severity of COVID-19 disease. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Antibiotics;10(11) |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source | Scientia |
dc.subject | COVID-19 (Malaltia) |
dc.subject | Antibiòtics |
dc.subject.mesh | Coronavirus Infections |
dc.subject.mesh | Anti-Bacterial Agents |
dc.subject.mesh | Correlation of Data |
dc.title | Correlation between previous antibiotic exposure and COVID-19 severity: a population-based cohort study |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/antibiotics10111364 |
dc.subject.decs | infecciones por Coronavirus |
dc.subject.decs | antibacterianos |
dc.subject.decs | correlación de datos |
dc.relation.publishversion | https://www.mdpi.com/2079-6382/10/11/1364 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.authoraffiliation | [Llor C] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Department of Public Health, General Practice, University of Southern Denmark, Odense, Denmark. [Ouchi D, Giner-Soriano M] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [García-Sangenís A] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. [Bjerrum L] Section and Research Unit of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. [Morros R] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Plataforma SCReN, IICEC IDIAP Jordi Gol, Barcelona, Spain |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |