dc.contributor | Institut d'Assistència Sanitària |
dc.contributor.author | Grothe, Michel |
dc.contributor.author | Labrador Espinosa, Miguel Ángel |
dc.contributor.author | Jesús Maestre, Silvia |
dc.contributor.author | Macias-Garcia, Daniel |
dc.contributor.author | Adarmes Gómez, Astrid Daniela |
dc.contributor.author | Carrillo, Fátima |
dc.contributor.author | Solano Vila, Berta |
dc.date.accessioned | 2021-11-12T08:42:45Z |
dc.date.available | 2021-11-12T08:42:45Z |
dc.date.issued | 2021-07 |
dc.identifier.citation | Grothe MJ, Labrador-Espinosa MA, Jesús S, Macías-García D, Adarmes-Gómez A, Carrillo F, et al. In vivo cholinergic basal forebrain degeneration and cognition in Parkinson’s disease: imaging results from the COPPADIS study. Parkinsonism Relat Disord. 2021 Jul;88:68-75. |
dc.identifier.issn | 1873-5126 |
dc.identifier.uri | https://hdl.handle.net/11351/6535 |
dc.description | Diffusion tensor imaging (DTI); Nucleus basalis Meynert; Parkinson's disease |
dc.description.abstract | The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models.
Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRStotal: r = 0.37, p < 0.001), and this association remained significant after controlling for several potential confounding variables (p = 0.004). Analysis of individual item scores showed that this association spanned executive and memory domains. No analogue cognition associations were observed for CBF MD. In covariate-controlled models, hippocampal volume was not associated with cognition in PD, but there was a significant association for hippocampal MD (p = 0.02).
Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition-relevant changes in non-demented PD. |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.relation.ispartofseries | Parkinsonism and Related Disorders;88 |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source | Scientia |
dc.subject | Parkinson, Malaltia de |
dc.subject | Ressonància magnètica |
dc.subject | Cervell - Imatgeria per ressonància magnètica |
dc.subject.mesh | Parkinson Disease |
dc.subject.mesh | Diffusion Tensor Imaging |
dc.subject.mesh | Basal Nucleus of Meynert |
dc.title | In vivo cholinergic basal forebrain degeneration and cognition in Parkinson’s disease: imaging results from the COPPADIS study |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1016/j.parkreldis.2021.05.027. |
dc.subject.decs | enfermedad de Parkinson |
dc.subject.decs | imagen por resonancia magnética |
dc.subject.decs | núcleo basal de Meynert |
dc.relation.publishversion | https://doi.org/10.1016/j.parkreldis.2021.05.027 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.event.productor | Biblioteca |
dc.contributor.authoraffiliation | [Grothe MJ, Labrador-Espinosa MA, Jesús S, Macías-García D, Adarmes-Gómez A] Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. [Carrillo F] Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. [Solano Vila B] Institut Catalá de la Salut (ICS), Girona, Spain. Institut d'Assisténcia Sanitaria (IAS), Salt, Spain |
dc.identifier.pmid | 34144230 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |