dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Rodríguez Sinovas, Antonio |
dc.contributor.author | Sanchez Garcia, Jose A |
dc.contributor.author | Valls de Lacalle, Laura |
dc.contributor.author | Consegal Perez, Marta |
dc.contributor.author | Ferreira González, Ignacio |
dc.date.accessioned | 2021-12-16T12:21:49Z |
dc.date.available | 2021-12-16T12:21:49Z |
dc.date.issued | 2021-04-23 |
dc.identifier.citation | Rodríguez-Sinovas A, Sánchez JA, Valls-Lacalle L, Consegal M, Ferreira-González I. Connexins in the Heart: Regulation, Function and Involvement in Cardiac Disease. Int J Mol Sci. 2021 Apr 23;22(9):4413. |
dc.identifier.issn | 1422-0067 |
dc.identifier.uri | https://hdl.handle.net/11351/6699 |
dc.description | Cardiomyocyte; Connexin; Mitochondria |
dc.description.abstract | Connexins are a family of transmembrane proteins that play a key role in cardiac physiology. Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes, allowing the existence of electrical coupling. However, in addition to this fundamental role, connexins are also involved in cardiomyocyte death and survival. Thus, chemical coupling through gap junctions plays a key role in the spreading of injury between connected cells. Moreover, in addition to their involvement in cell-to-cell communication, mounting evidence indicates that connexins have additional gap junction-independent functions. Opening of unopposed hemichannels, located at the lateral surface of cardiomyocytes, may compromise cell homeostasis and may be involved in ischemia/reperfusion injury. In addition, connexins located at non-canonical cell structures, including mitochondria and the nucleus, have been demonstrated to be involved in cardioprotection and in regulation of cell growth and differentiation. In this review, we will provide, first, an overview on connexin biology, including their synthesis and degradation, their regulation and their interactions. Then, we will conduct an in-depth examination of the role of connexins in cardiac pathophysiology, including new findings regarding their involvement in myocardial ischemia/reperfusion injury, cardiac fibrosis, gene transcription or signaling regulation. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | International Journal of Molecular Sciences;22(9) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Cor - Malalties |
dc.subject | Cor - Fisiologia patològica |
dc.subject | Connexines - Metabolisme |
dc.subject.mesh | Heart Diseases |
dc.subject.mesh | /physiopathology |
dc.subject.mesh | Connexins |
dc.subject.mesh | /metabolism |
dc.title | Connexins in the Heart: Regulation, Function and Involvement in Cardiac Disease |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/ijms22094413 |
dc.subject.decs | enfermedades cardíacas |
dc.subject.decs | /fisiopatología |
dc.subject.decs | conexinas |
dc.subject.decs | /metabolismo |
dc.relation.publishversion | https://doi.org/10.3390/ijms22094413 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Rodríguez-Sinovas A, Sánchez JA, Valls-Lacalle L, Consegal M] Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red sobre Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain. [Ferreira-González I] Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red (CIBER) de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain |
dc.identifier.pmid | 33922534 |
dc.identifier.wos | 000650389600001 |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/PE2013-2016/PI17%2F01397 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |