dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Vilchez, Helem H. |
dc.contributor.author | Escudero-Sanchez, Rosa |
dc.contributor.author | Fernandez-Sampedro, Marta |
dc.contributor.author | Murillo, Oscar |
dc.contributor.author | Auñón, Álvaro |
dc.contributor.author | Rodríguez Pardo, Ma Dolores |
dc.date.accessioned | 2021-12-17T11:03:57Z |
dc.date.available | 2021-12-17T11:03:57Z |
dc.date.issued | 2021-04-21 |
dc.identifier.citation | Vilchez HH, Escudero-Sanchez R, Fernandez-Sampedro M, Murillo O, Auñón Á, Rodríguez-Pardo D, et al. Prosthetic Shoulder Joint Infection by Cutibacterium acnes: Does Rifampin Improve Prognosis? A Retrospective, Multicenter, Observational Study. Antibiotics. 2021 Apr 21;10(5):475. |
dc.identifier.issn | 2079-6382 |
dc.identifier.uri | https://hdl.handle.net/11351/6706 |
dc.description | Cutibacterium acnes; Prosthetic joint infection; Surgical and medical treatment |
dc.description.abstract | This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes-related PJI who were diagnosed and treated between January 2003 and December 2016 were included. We analyzed 44 patients with C. acnes-related PJI (median age, 67.5 years (IQR, 57.3–75.8)); 75% were men. The majority (61.4%) had late chronic infection according to the Tsukayama classification. All patients received surgical treatment, and most antibiotic regimens (43.2%) included β-lactam. Thirty-four patients (87.17%) were cured; five showed relapse. The final outcome (cure vs. relapse) showed a nonsignificant trend toward higher failure frequency among patients with previous prosthesis (OR: 6.89; 95% CI: 0.80–58.90) or prior surgery and infection (OR: 10.67; 95% IC: 1.08–105.28) in the same joint. Patients treated with clindamycin alone had a higher recurrence rate (40.0% vs. 8.8%). Rifampin treatment did not decrease recurrence in patients treated with β-lactams. Prior prosthesis, surgery, or infection in the same joint might be related to recurrence, and rifampin-based combinations do not seem to improve prognosis. Debridement and implant retention appear a safe option for surgical treatment of early PJI. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Antibiotics;10(5) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Malalties bacterianes - Tractament |
dc.subject | Medicaments antibacterians - Ús terapèutic |
dc.subject | Articulacions artificials |
dc.subject.mesh | Prosthesis-Related Infections |
dc.subject.mesh | /drug therapy |
dc.subject.mesh | Gram-Positive Bacterial Infections |
dc.subject.mesh | Anti-Bacterial Agents |
dc.title | Prosthetic Shoulder Joint Infection by Cutibacterium acnes: Does Rifampin Improve Prognosis? A Retrospective, Multicenter, Observational Study |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/antibiotics10050475 |
dc.subject.decs | infecciones relacionadas con prótesis |
dc.subject.decs | /farmacoterapia |
dc.subject.decs | infecciones por bacterias grampositivas |
dc.subject.decs | antibacterianos |
dc.relation.publishversion | https://doi.org/10.3390/antibiotics10050475 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Vilchez HH] Infectious Diseases Unit, Internal Medicine Department, Hospital Universitari Son Espases, Fundació Institut d’Investigació Sanitària Illes Balears (IdISBa), 07120 Palma de Mallorca, Spain. [Escudero-Sanchez R] Infectious Diseases Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain. [Fernandez-Sampedro M] Infectious Diseases Unit, Department of Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, 39008 Cantabria, Spain. [Murillo O] Infectious Diseases Department, Hospital Universitari de Bellvitge, 08907 Barcelona, Spain. [Auñón Á] Bone and Joint Infection Unit, Department of Orthopaedic Surgery, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain. [Rodríguez-Pardo D] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain |
dc.identifier.pmid | 33919103 |
dc.identifier.wos | 000653356600001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |