dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Tobler, Daniel |
dc.contributor.author | Greutmann, Matthias |
dc.contributor.author | Bouchardy, Judith |
dc.contributor.author | Ladouceur, Magalie |
dc.contributor.author | Dos Subirá, Laura |
dc.contributor.author | Ruperti-Repilado, Francisco Javier |
dc.date.accessioned | 2021-12-21T13:39:38Z |
dc.date.available | 2021-12-21T13:39:38Z |
dc.date.issued | 2021-04-21 |
dc.identifier.citation | Ruperti-Repilado FJ, Tobler D, Greutmann M, Bouchardy J, Ladouceur M, Dos-Subira L, et al. Risk stratification of adults with congenital heart disease during the COVID-19 pandemic: insights from a multinational survey among European experts. Open Heart. 2021 Apr 21;8:e001455. |
dc.identifier.issn | 2053-3624 |
dc.identifier.uri | https://hdl.handle.net/11351/6720 |
dc.description | Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Congenital; Heart defects |
dc.description.abstract | Objective Adults with congenital heart disease (ACHD) may be at a higher risk of a fatal outcome in case of COVID-19. Current risk stratification among these patients relies on personal experience and extrapolation from patients with acquired heart disease. We aimed to provide an expert view on risk stratification while awaiting results from observational studies.
Methods This study was an initiative of the EPOCH (European Collaboration for Prospective Outcome Research in Congenital Heart disease). Among nine European countries (Austria, Belgium, Denmark, France, Germany, Italy, the Netherlands, Spain and Switzerland), 24 experts from 23 tertiary ACHD centres participated in the survey. ACHD experts were asked to identify ACHD-specific COVID-19 risk factors from a list of potential outcome predictors and to estimate the risk of adverse COVID-19 outcomes in seven commonly seen patient scenarios.
Results 82% of participants did not consider all ACHD patients at risk of COVID-19 related complications. There was a consensus on pulmonary arterial hypertension, Fontan physiology and cyanotic heart disease as risk factors for adverse outcomes. Among different ACHD scenarios, a patient with Eisenmenger syndrome was considered to be at the highest risk. There was a marked variability in risk estimation among the other potential outcome predictors and ACHD scenarios.
Conclusions Pulmonary arterial hypertension, Fontan palliation and cyanotic heart disease were widely considered as risk factors for poor outcome in COVID-19. However, there was a marked disparity in risk estimation for other clinical scenarios. We are in urgent need of outcome studies in ACHD suffering from COVID-19. |
dc.language.iso | eng |
dc.publisher | BMJ |
dc.relation.ispartofseries | Open heart;8 |
dc.rights | Attribution-NonCommercial 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ |
dc.source | Scientia |
dc.subject | Pandèmia de COVID-19, 2020- |
dc.subject | Cardiopatia congènita |
dc.subject | Riscos per a la salut - Avaluació |
dc.subject.mesh | Heart Defects, Congenital |
dc.subject.mesh | Coronavirus Infections |
dc.subject.mesh | Risk Assessment |
dc.title | Risk stratification of adults with congenital heart disease during the COVID-19 pandemic: insights from a multinational survey among European experts |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1136/openhrt-2020-001455 |
dc.subject.decs | cardiopatías congénitas |
dc.subject.decs | infecciones por Coronavirus |
dc.subject.decs | evaluación de riesgos |
dc.relation.publishversion | http://dx.doi.org/10.1136/openhrt-2020-001455 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Ruperti-Repilado FJ] Center for Congenital Heart Disease, Cardiology, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland. [Tobler D] Division of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland. [Greutmann M] University Heart Centre Zurich, Department of Cardiology, University of Zurich, Zurich, Switzerland. [Bouchardy J] Cardiovascular Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Service de Cardiologie, University Hospital of Geneva, Geneve, Switzerland. [Ladouceur M] Adult Congenital Heart Disease Unit, Centre de Référence des Malformations Cardiaques Congénitales Complexes, M3C, Inserm U970, Paris Centre de Recherche Cardiovasculaire, Hôpital Europeen Georges-Pompidou Pôle Cardio-vasculaire Rénal Métabolique, Paris, France. [Dos-Subira L] Unitat Integrada de Cardiopaties Congènites de l'Adolescent i l'Adult, Vall d'Hebron Hospital Universitari, Barcelona, Spain - Sant Pau. CIBERCV, Barcelona, Spain |
dc.identifier.pmid | 33883228 |
dc.identifier.wos | 000644328900002 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |