dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Ciardiello, Davide |
dc.contributor.author | Martin, Giulia |
dc.contributor.author | Famiglietti, Vincenzo |
dc.contributor.author | Napolitano, Stefania |
dc.contributor.author | Troiani, Teresa |
dc.contributor.author | Ros Montañá, Fco. Javier |
dc.contributor.author | Elez Fernandez, Mª Elena |
dc.contributor.author | De Falco, Vincenzo |
dc.date.accessioned | 2021-12-28T07:36:04Z |
dc.date.available | 2021-12-28T07:36:04Z |
dc.date.issued | 2021-04-17 |
dc.identifier.citation | Ciardiello D, Martini G, Famiglietti V, Napolitano S, De Falco V, Troiani T, et al. Biomarker-Guided Anti-Egfr Rechallenge Therapy in Metastatic Colorectal Cancer. Cancers. 2021 Apr 17;13(8):1941. |
dc.identifier.issn | 2072-6694 |
dc.identifier.uri | https://hdl.handle.net/11351/6741 |
dc.description | Anti-EGFR monoclonal antibodies; Metastatic colorectal cancer |
dc.description.abstract | The prognosis of patients with metastatic colorectal cancer (mCRC) who progressed to the first and the second lines of treatment is poor. Thus, new therapeutic strategies are needed. During the last years, emerging evidence suggests that retreatment with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MAbs) in the third line of mCRC patients, that have previously obtained clinical benefit by first-line therapy with anti-EGFR MAbs plus chemotherapy, could lead to prolonged survival. The rationale beyond this “rechallenge” strategy is that, after disease progression to first line EGFR-based therapy, a treatment break from anti-EGFR drugs results in RAS mutant cancer cell decay, restoring the sensitivity of cancer cells to cetuximab and panitumumab. In fact, rechallenge treatment with anti-EGFR drugs has shown promising clinical activity, particularly in patients with plasma RAS and BRAF wild type circulating tumor DNA, as defined by liquid biopsy analysis at baseline treatment. The aim of this review is to analyze the current knowledge on rechallenge and to investigate the role of novel biomarkers that can guide the appropriate selection of patients that could benefit from this therapeutic strategy. Finally, we discuss on-going trials and future perspectives. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Cancers;13(8) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Còlon - Càncer -Tractament |
dc.subject | Recte - Càncer - Tractament |
dc.subject | Metàstasi |
dc.subject.mesh | Colorectal Neoplasms |
dc.subject.mesh | /drug therapy |
dc.subject.mesh | Antineoplastic Agents |
dc.subject.mesh | /therapeutic use |
dc.title | Biomarker-Guided Anti-Egfr Rechallenge Therapy in Metastatic Colorectal Cancer |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/cancers13081941 |
dc.subject.decs | neoplasias colorrectales |
dc.subject.decs | /farmacoterapia |
dc.subject.decs | antineoplásicos |
dc.subject.decs | /uso terapéutico |
dc.relation.publishversion | https://doi.org/10.3390/cancers13081941 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Ciardiello D] Oncologia Medica, Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, 80131 Naples, Italy. Oncologia Medica, Ospedale Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy. [Martini G, Famiglietti V, Napolitano S, De Falco V, Troiani T] Oncologia Medica, Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, 80131 Naples, Italy. [Ros J] Oncologia Medica, Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, 80131 Naples, Italy. Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. IOB-Quiron, UVic-UCC, 08035 Barcelona, Spain. [Elez Fernandez E] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. IOB-Quiron, UVic-UCC, 08035 Barcelona, Spain |
dc.identifier.pmid | 33920531 |
dc.identifier.wos | 000643969100001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |