dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Pons Delgado, Mònica |
dc.contributor.author | Nuñez Dubon, Alexa Gabriela |
dc.contributor.author | Esquinas López, Cristina |
dc.contributor.author | Torres-Durán, María |
dc.contributor.author | Rodríguez-Hermosa, Luis |
dc.contributor.author | Calle, Myriam |
dc.contributor.author | Belmonte Mula, Irene |
dc.contributor.author | Rodríguez Frias, Francisco |
dc.contributor.author | Rodríguez González, Esther |
dc.contributor.author | Genescà Ferrer, Joan |
dc.contributor.author | Miravitlles Fernández, Marc |
dc.contributor.author | Barrecheguren Fernández, Miriam |
dc.date.accessioned | 2021-12-28T07:48:04Z |
dc.date.available | 2021-12-28T07:48:04Z |
dc.date.issued | 2021-04-16 |
dc.identifier.citation | Pons M, Núñez A, Esquinas C, Torres-Durán M, Rodríguez-Hermosa JL, Calle M, et al. Utility of Transient Elastography for the Screening of Liver Disease in Patients with Alpha1-Antitrypsin Deficiency. J Clin Med. 2021 Apr 16;10(8):1724. |
dc.identifier.issn | 2077-0383 |
dc.identifier.uri | https://hdl.handle.net/11351/6743 |
dc.description | Alpha1-antitrypsin deficiency; Liver disease; Transient elastography |
dc.description.abstract | Screening of liver disease in alpha-1 antitrypsin deficiency (AATD) is usually carried out with liver enzymes, with low sensitivity. We conducted a multicenter cross-sectional study aiming to describe the utility of transient elastography for the identification of liver disease in patients with AATD. A total of 148 AATD patients were included. Among these, 54.7% were Pi*ZZ and 45.3% were heterozygous for the Z allele. Between 4.9% and 16.5% of patients had abnormal liver enzymes, without differences among genotypes. Liver stiffness measurement (LSM) was significantly higher in Pi*ZZ individuals than in heterozygous Z (5.6 vs. 4.6 kPa; p = 0.001). In total, in 8 (5%) individuals LSM was >7.5 kPa, considered significant liver fibrosis, and ≥10 kPa in 3 (1.9%) all being Pi*ZZ. Elevated liver enzymes were more frequently observed in patients with LSM > 7.5 kPa, but in 5 out of 8 of these patients all liver enzymes were within normal range. In patients with AATD, the presence of abnormal liver enzymes is frequent; however, most of these patients do not present significant liver fibrosis. Transient elastography can help to identify patients with liver fibrosis even with normal liver enzymes and should be performed in all Z-allele carriers to screen for liver disease. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Journal of Clinical Medicine;10(8) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Alfa 1-antitripsina |
dc.subject | Fetge - Malalties - Imatgeria |
dc.subject.mesh | Elasticity Imaging Techniques |
dc.subject.mesh | Liver Diseases |
dc.subject.mesh | /diagnostic imaging |
dc.subject.mesh | alpha 1-Antitrypsin Deficiency |
dc.title | Utility of Transient Elastography for the Screening of Liver Disease in Patients with Alpha1-Antitrypsin Deficiency |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/jcm10081724 |
dc.subject.decs | elastografía |
dc.subject.decs | enfermedades hepáticas |
dc.subject.decs | /diagnóstico por imagen |
dc.subject.decs | deficiencia de alfa 1-antitripsina |
dc.relation.publishversion | https://doi.org/10.3390/jcm10081724 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Pons M] Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Núñez A, Esquinas C] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Torres-Durán M] Pneumology Department, University Hospital Complex of Vigo, Instituto de Investigación Biomédica Galicia Sur, 36213 Vigo, Spain. [Rodríguez-Hermosa JL, Calle M] Pneumology Department, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico de San Carlos, Departamento de Medicina, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain. [Belmonte I, Rodríguez E, Barrecheguren M] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Rodríguez-Frías F] Servei de Bioquímica Clínica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029 Madrid, Spain. [Genescà J] Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029 Madrid, Spain. [Miravitlles M] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain |
dc.identifier.pmid | 33923569 |
dc.identifier.wos | 000644471600001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |