dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Escudero Monreal, Laura |
dc.contributor.author | Martínez Ricarte, Francisco Ramón |
dc.contributor.author | Seoane Suarez, Joan |
dc.date.accessioned | 2021-12-28T10:35:47Z |
dc.date.available | 2021-12-28T10:35:47Z |
dc.date.issued | 2021-04-21 |
dc.identifier.citation | Escudero L, Martínez-Ricarte F, Seoane J. ctDNA-Based Liquid Biopsy of Cerebrospinal Fluid in Brain Cancer. Cancers. 2021 Apr 21;13(9):1989. |
dc.identifier.issn | 2072-6694 |
dc.identifier.uri | https://hdl.handle.net/11351/6752 |
dc.description | Brain cancer; Circulating tumour DNA; Liquid biopsies |
dc.description.abstract | The correct characterisation of central nervous system (CNS) malignancies is crucial for accurate diagnosis and prognosis and also the identification of actionable genomic alterations that can guide the therapeutic strategy. Surgical biopsies are performed to characterise the tumour; however, these procedures are invasive and are not always feasible for all patients. Moreover, they only provide a static snapshot and can miss tumour heterogeneity. Currently, monitoring of CNS cancer is performed by conventional imaging techniques and, in some cases, cytology analysis of the cerebrospinal fluid (CSF); however, these techniques have limited sensitivity. To overcome these limitations, a liquid biopsy of the CSF can be used to obtain information about the tumour in a less invasive manner. The CSF is a source of cell-free circulating tumour DNA (ctDNA), and the analysis of this biomarker can characterise and monitor brain cancer. Recent studies have shown that ctDNA is more abundant in the CSF than plasma for CNS malignancies and that it can be sequenced to reveal tumour heterogeneity and provide diagnostic and prognostic information. Furthermore, analysis of longitudinal samples can aid patient monitoring by detecting residual disease or even tracking tumour evolution at relapse and, therefore, tailoring the therapeutic strategy. In this review, we provide an overview of the potential clinical applications of the analysis of CSF ctDNA and the challenges that need to be overcome in order to translate research findings into a tool for clinical practice. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Cancers;13(9) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Sistema nerviós central - Malalties - Diagnòstic |
dc.subject | Líquid cefaloraquidi - Biòpsia |
dc.subject.mesh | Central Nervous System Neoplasms |
dc.subject.mesh | Circulating Tumor DNA |
dc.subject.mesh | /cerebrospinal fluid |
dc.subject.mesh | Liquid Biopsy |
dc.title | ctDNA-Based Liquid Biopsy of Cerebrospinal Fluid in Brain Cancer |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/cancers13091989 |
dc.subject.decs | neoplasias del sistema nervioso central |
dc.subject.decs | ADN tumoral circulante |
dc.subject.decs | /líquido cefalorraquídeo |
dc.subject.decs | biopsia líquida |
dc.relation.publishversion | https://doi.org/10.3390/cancers13091989 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Escudero L] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain, Barcelona, Spain. [Martínez-Ricarte F] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Seoane J] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERONC (Centro de Investigación Biomédica en Red de Cáncer), Instituto de Salud Carlos III, 28029 Madrid, Spain. ICREA (Institució Catalana de Recerca i Estudis Avançats), 08010 Barcelona, Spain |
dc.identifier.pmid | 33919036 |
dc.identifier.wos | 000649881600001 |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/PE2017-2020/PI19%2F00318 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |