dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Bastida, Guillermo |
dc.contributor.author | Herrera de Guise, Claudia Maria |
dc.contributor.author | Algaba, Alicia |
dc.contributor.author | Ber Nieto, Yolanda |
dc.contributor.author | Soares, Jose Manuel |
dc.contributor.author | Robles Alonso, Virginia |
dc.date.accessioned | 2022-01-17T07:00:20Z |
dc.date.available | 2022-01-17T07:00:20Z |
dc.date.issued | 2021-05-22 |
dc.identifier.citation | Bastida G, Herrera-de Guise C, Algaba A, Ber Nieto Y, Soares JM, Robles V, et al. Sucrosomial Iron Supplementation for the Treatment of Iron Deficiency Anemia in Inflammatory Bowel Disease Patients Refractory to Oral Iron Treatment. Nutrients. 2021 May 22;13(6):1770. |
dc.identifier.issn | 2072-6643 |
dc.identifier.uri | https://hdl.handle.net/11351/6808 |
dc.description | Inflammatory bowel disease; Iron deficiency; Iron supplementation |
dc.description.abstract | Iron deficiency anemia (IDA) is a common manifestation of Inflammatory Bowel Disease (IBD). Oral iron supplements are the treatment of choice, but are not always well tolerated. Sucrosomial® iron (SI) may represent an alternative. This prospective study assessed the tolerability and effectiveness of SI, and quality of life (QoL) of IDA-IBD patients who were intolerant to oral iron salts. The study included 52 individuals treated with 1 capsule/day for 12 weeks. Tolerability was assessed through a gastrointestinal symptom severity questionnaire. Hemoglobin (Hb) levels and clinical symptoms of IDA were analyzed. QoL was assessed using IBDQ-9 and EuroQoL questionnaires. The percentage of patients with excellent/good health increased from 42.9% to 94.3%. Mean Hb concentration significantly increased at all follow-up visits (p < 0.05). Almost all participants (96.9%) were adherent to the study medication. Patients’ QoL improved (IBDQ-9: from 60.9 to 65.5). Patients also improved in mobility (71.8% to 78.1%), usual activities (51.3% to 68.7%), pain/discomfort (41.0% to 53.1%), and extreme depression/anxiety problems (7.7% to 3.2%); they worsened in self-care (100% to 90.6%), but perceived an enhancement in their global health [EQ-VAS score: 61.9 (±26.1) to 66.9 (±20.3)]. SI was well tolerated and improved IDA symptoms, IBD activity, and patients’ QoL. In conclusion, SI should be considered in IDA–IBD patients. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Nutrients;13(6) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Intestins - Inflamació - Tractament |
dc.subject | Anèmia ferropènica - Tractament |
dc.subject | Ferro - Metabolisme - Ús terapèutic |
dc.subject.mesh | Inflammatory Bowel Diseases |
dc.subject.mesh | Anemia, Iron-Deficiency |
dc.subject.mesh | Iron |
dc.subject.mesh | /administration & dosage |
dc.title | Sucrosomial Iron Supplementation for the Treatment of Iron Deficiency Anemia in Inflammatory Bowel Disease Patients Refractory to Oral Iron Treatment |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/nu13061770 |
dc.subject.decs | enfermedad inflamatoria intestinal |
dc.subject.decs | anemia ferropénica |
dc.subject.decs | hierro |
dc.subject.decs | /administración & dosificación |
dc.relation.publishversion | https://doi.org/10.3390/nu13061770 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Bastida G] Department of Gastroenterology, CIBEREHD, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain. [Herrera-de Guise C, Robles V] Unitat d'Atenció a la Colitis de Crohn, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Algaba A] Department of Gastroenterology, Instituto de Investigación Sanitaria Hospital La Paz (IdiPaz), Hospital Universitario de Fuenlabrada, 28046 Madrid, Spain. [Ber Nieto Y] Department of Gastroenterology, Hospital Universitario San Jorge, 22004 Huesca, Spain. [Soares JM] Department of Gastroenterology, Hospital Pedro Hispano, 4454-509 Matosinhos, Portugal |
dc.identifier.pmid | 34067320 |
dc.identifier.wos | 000666753400001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |