Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up
dc.contributor | Institut d'Assistència Sanitària |
dc.contributor.author | de Deus Fonticoba, Teresa |
dc.contributor.author | Cores Bartolomé, Carlos |
dc.contributor.author | Canfield, Hector |
dc.contributor.author | Aguilar, Miquel |
dc.contributor.author | Cosgaya, Marina |
dc.contributor.author | Caballol, Nuria |
dc.contributor.author | Ávila Rivera, María A. |
dc.contributor.author | Nogueira, Víctor |
dc.contributor.author | Solano Vila, Berta |
dc.contributor.author | Cubo, Esther |
dc.contributor.author | Carrillo Padilla, Francisco |
dc.contributor.author | Martinez Castrillo, Juan Carlos |
dc.contributor.author | Sánchez Alonso, Pilar |
dc.contributor.author | Alonso Losada, Maria G. |
dc.contributor.author | López-Ariztegui, Nuria |
dc.contributor.author | Gastón, Itziar |
dc.contributor.author | Kulisevsky, Jaime |
dc.contributor.author | Blázquez Estrada, Marta |
dc.contributor.author | Seijo, Manuel |
dc.contributor.author | Ruiz-Martinez, Javier |
dc.contributor.author | Valero, Caridad |
dc.contributor.author | Kurtis, Mónica |
dc.contributor.author | de Fabregues-Boixar Nebot, Oriol |
dc.contributor.author | González Ardura, Jessica |
dc.contributor.author | Alonso Redondo, Ruben |
dc.contributor.author | Ordás, Carlos |
dc.contributor.author | López Díaz, Luis M. |
dc.contributor.author | McAfee, Darrian |
dc.contributor.author | Martinez-Martin, Pablo |
dc.contributor.author | Mir, Pablo |
dc.contributor.author | Garcia-Caldentey, Juan |
dc.contributor.author | Legarda, Ines |
dc.contributor.author | Cabo López, Iria |
dc.contributor.author | Gonzalez-Aramburu, Isabel |
dc.contributor.author | Gómez-Mayordomo, Víctor |
dc.contributor.author | Pastor, Pau |
dc.contributor.author | Lopez Manzanares, Lydia |
dc.contributor.author | Puente, Victor |
dc.contributor.author | Dotor, Julio |
dc.contributor.author | borrue fernandez, carmen |
dc.contributor.author | Alvarez Sauco, Maria |
dc.contributor.author | Vela-Desojo, Lydia |
dc.contributor.author | Escalante Arroyo, Sonia |
dc.contributor.author | JESUS MAESTRE, SILVIA |
dc.contributor.author | HERNANDEZ-VARA, JORGE |
dc.contributor.author | Naya Ríos, Lucía |
dc.contributor.author | García Roca, Lucía |
dc.contributor.author | Feal, María |
dc.contributor.author | Santos García, Diego |
dc.contributor.author | MARTINEZ MIRO, CRISTINA |
dc.date.accessioned | 2022-01-26T12:02:41Z |
dc.date.available | 2022-01-26T12:02:41Z |
dc.date.issued | 2021-12-17 |
dc.identifier.citation | Santos García D, Naya Ríos L, de Deus Fonticoba T, Cores Bartolomé C, García Roca L, Feal Painceiras M, et al. Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up. Diagnostics. 2021 Dec 17;11(12):2380. |
dc.identifier.issn | 2075-4418 |
dc.identifier.uri | https://hdl.handle.net/11351/6907 |
dc.description | Parkinson’s disease; Phenotype; Tremor |
dc.description.abstract | Background and objective: Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it. Patients and Methods: PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as “with diplopia” or “without diplopia” according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls. Results: The frequency of diplopia in the PD patients was 13.6% (94/691) at V0 (1.9% in controls [4/206]; p < 0.0001), 14.2% (86/604) at V1, and 17.1% (86/502) at V2 (0.8% in controls [1/124]; p < 0.0001), with a period prevalence of 24.9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2.264; 95%CI, 1.269–4.039; p = 0.006), a higher score on the NMSS at V0 (OR = 1.009; 95%CI, 1.012–1.024; p = 0.015), and a greater increase from V0 to V2 on the Unified Parkinson’s Disease Rating Scale–III (OR = 1.039; 95%CI, 1.023–1.083; p < 0.0001) and Neuropsychiatric Inventory (OR = 1.028; 95%CI, 1.001–1.057; p = 0.049) scores were independent factors associated with diplopia (R2 = 0.25; Hosmer and Lemeshow test, p = 0.716). Conclusions: Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Diagnostics;11(12) |
dc.rights | Attribution-ShareAlike 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ |
dc.source | Scientia |
dc.subject | Parkinson, Malaltia de |
dc.subject | Fenotip |
dc.subject | Tremolor |
dc.subject.mesh | Parkinson Disease |
dc.subject.mesh | Phenotype |
dc.subject.mesh | Tremor |
dc.title | Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/diagnostics11122380 |
dc.subject.decs | enfermedad de Parkinson |
dc.subject.decs | fenotipo |
dc.subject.decs | temblor |
dc.relation.publishversion | https://doi.org/10.3390/diagnostics11122380 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.event.productor | Biblioteca |
dc.contributor.authoraffiliation | [Santos-García D, Naya Rios L, Cores Bartolomé C, García Roca L, Feal Painceiras M, Martínez Miró C] Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain. [de Deus Fonticoba T, Canfield H] Complejo Hospitalario Universitario de Ferrol (CHUF), A Coruña, Spain. [Jesús S, Mir P] Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain. Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. [Aguilar M, Pastor P] Hospital Universitari Mutua de Terrassa, Terrassa , Spain. [Cosgaya M] Hospital Clínic de Barcelona, Barcelona, Spain. [García-Caldentey J] Centro Neurológico Oms, Palma de Mallorca, Spain. [Caballol N] Consorci Sanitari Integral, Hospital Moisés Broggi, Barcelona, Spain. [Legarda I] Hospital Universitari Son Espases, Palma de Mallorca, Spain. [Hernández-Vara J, de Fábregues O] Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Cabo López I, Seijo M] Complexo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain. [López Manzanares L] Hospital Universitario La Princesa, Madrid, Spain. [González Aramburu I] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Hospital Universitario Marqués de Valdecilla, Santander, Spain. [Ávila Rivera MA] Consorci Sanitari Integral, Hospital General de L'Hospitalet, L'Hospitalet de Llobregat, Spain. [Gómez-Mayordomo V] Hospital Universitario Clínico San Carlos, Madrid, Spain. [Nogueira V] Hospital Da Costa, Burela, Lugo, Spain. [Puente V] Hospital del Mar, Barcelona, Spain. [Dotor J] Hospital Universitario Virgen Macarena, Sevilla, Spain. [Borrué C] Hospital Infanta Sofía, Madrid, Spain. [Solano Vila B] Institut d'Assistència Sanitària (IAS), Institut Català de la Salut (ICS), Salt, Spain. [Álvarez Sauco M] Hospital General Universitario de Elche, Elche, Spain. [Vela-Desojo L] Fundación Hospital de Alcorcón, Madrid, Spain. [Escalante S] Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Spain. [Cubo E] Complejo Asistencial Universitario de Burgos, Burgos, Spain. [Carrillo-Padilla F] Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. [Martínez Castrillo JC] Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain. [Sánchez Alonso P] Hospital Universitario Puerta de Hierro, Madrid, Spain. [Alonso Losada MG] Hospital Álvaro Cunqueiro, Complexo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain. [López-Ariztegui N] Complejo Hospitalario de Toledo, Toledo, Spain. [Gastón I] Complejo Hospitalario de Navarra, Pamplona, Spain. [Kulisevsky J] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Hospital de Sant Pau, Barcelona, Spain. [Blázquez Estrada M] Hospital Universitario Central de Asturias, Oviedo, Spain. [Ruiz-Martínez J] Hospital Universitario Donostia, San Sebastián, Spain. [Valero C] Hospital Arnau de Vilanova, València, Spain. [Kurtis M] Hospital Ruber Internacional, Madrid, Spain. [González Ardura J] Hospital de Cabueñes, Gijón, Spain. [Alonso Redondo R] Universitario Lucus Augusti (HULA), Lugo, Spain. [Ordás C] Hospital Rey Juan Carlos, Madrid, Spain. [López Díaz LM] Complexo Hospitalario Universitario de Ourense (CHUO), Ourense, Spain. [McAfee D] University of Maryland School of Medicine, Baltimore, USA. [Martinez-Martin P] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain |
dc.identifier.pmid | 34943619 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |
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