dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Buxeda, Anna |
dc.contributor.author | Said, Samar |
dc.contributor.author | Nasr, Samih H. |
dc.contributor.author | Soler Romeo, Maria Jose |
dc.contributor.author | Howard, Mathew T. |
dc.contributor.author | Maguire, Leo J. |
dc.date.accessioned | 2022-02-22T07:41:55Z |
dc.date.available | 2022-02-22T07:41:55Z |
dc.date.issued | 2021-07 |
dc.identifier.citation | Buxeda A, Said S, Nasr SH, Soler MJ, Howard MT, Maguire LJ, et al. Crystal-Induced Podocytopathy Producing Collapsing Focal Segmental Glomerulosclerosis in Monoclonal Gammopathy of Renal Significance: A Case Report. Kidney Med. 2021 Jul;3(4):659–64. |
dc.identifier.issn | 2590-0595 |
dc.identifier.uri | https://hdl.handle.net/11351/7054 |
dc.description | Focal and segmental glomerulosclerosis; Crystalline keratopathy; Podocytopathy |
dc.description.abstract | Monoclonal gammopathy–associated crystalline podocytopathy causing collapsing focal segmental glomerulosclerosis (FSGS) is very rare and has been associated with pamidronate therapy. We present the case of a 53-year-old man with vision loss secondary to corneal crystals deposition, nephrotic-range proteinuria, and reduced glomerular filtration rate without associated comorbid conditions. Two kidney biopsies were initially reported as primary FSGS but the patient did not respond to high-dose corticosteroid immunosuppression therapy. Re-review of biopsies with additional electron microscopy analysis revealed crystalline inclusions in podocytes leading to collapsing FSGS. Subsequent workup revealed an immunoglobulin G κ serum monoclonal protein. Bone marrow biopsy revealed 5% κ-restricted plasma cells with cytoplasmic crystalline inclusions. To our knowledge, this is the first case of monoclonal gammopathy of clinical significance manifesting as crystalline podocytopathy leading to collapsing FSGS and keratopathy leading to vision loss. Crystalline podocytopathy should be considered in the differential diagnosis of collapsing glomerulopathy, and careful ultrastructural examination of the kidney biopsy specimen is crucial to establish this diagnosis. |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.relation.ispartofseries | Kidney Medicine;3(4) |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source | Scientia |
dc.subject | Glomèruls renals - Malalties - Complicacions |
dc.subject | Gammapaties monoclonals - Complicacions |
dc.subject.mesh | Glomerulosclerosis, Focal Segmental |
dc.subject.mesh | /complications |
dc.subject.mesh | Monoclonal Gammopathy of Undetermined Significance |
dc.subject.mesh | /complications |
dc.title | Crystal-Induced Podocytopathy Producing Collapsing Focal Segmental Glomerulosclerosis in Monoclonal Gammopathy of Renal Significance: A Case Report |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1016/j.xkme.2021.03.007 |
dc.subject.decs | glomeruloesclerosis focal |
dc.subject.decs | /complicaciones |
dc.subject.decs | gammopatía monoclonal de relevancia indeterminada |
dc.subject.decs | /complicaciones |
dc.relation.publishversion | https://doi.org/10.1016/j.xkme.2021.03.007 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Buxeda A] Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN. Division of Nephrology, Hospital del Mar, Barcelona, Spain. [Said S, Samih H. Nasr] Division of Anatomic Pathology, Mayo Clinic College of Medicine, Rochester, MN. [Soler MJ] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Howard MT] Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN. [Maguire LJ] Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN |
dc.identifier.pmid | 34401732 |
dc.identifier.wos | 000685916200023 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |