dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Montaña Ernst, Lena Nerea |
dc.contributor.author | Casals, Eudald |
dc.contributor.author | Italiani, Paola |
dc.contributor.author | Boraschi, Diana |
dc.contributor.author | Franco Puntes, Victor |
dc.date.accessioned | 2022-03-21T09:04:02Z |
dc.date.available | 2022-03-21T09:04:02Z |
dc.date.issued | 2021-11-06 |
dc.identifier.citation | Ernst LM, Casals E, Italiani P, Boraschi D, Puntes V. The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective. Nanomaterials. 2021 Nov 6;11(11):2991. |
dc.identifier.issn | 2079-4991 |
dc.identifier.uri | https://hdl.handle.net/11351/7215 |
dc.description | Inflammation; Innate immunity; Nanoparticles |
dc.description.abstract | The immune system contributes to maintaining the body’s functional integrity through its two main functions: recognizing and destroying foreign external agents (invading microorganisms) and identifying and eliminating senescent cells and damaged or abnormal endogenous entities (such as cellular debris or misfolded/degraded proteins). Accordingly, the immune system can detect molecular and cellular structures with a spatial resolution of a few nm, which allows for detecting molecular patterns expressed in a great variety of pathogens, including viral and bacterial proteins and bacterial nucleic acid sequences. Such patterns are also expressed in abnormal cells. In this context, it is expected that nanostructured materials in the size range of proteins, protein aggregates, and viruses with different molecular coatings can engage in a sophisticated interaction with the immune system. Nanoparticles can be recognized or passed undetected by the immune system. Once detected, they can be tolerated or induce defensive (inflammatory) or anti-inflammatory responses. This paper describes the different modes of interaction between nanoparticles, especially inorganic nanoparticles, and the immune system, especially the innate immune system. This perspective should help to propose a set of selection rules for nanosafety-by-design and medical nanoparticle design. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Nanomaterials;11(11) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Sistema immunològic |
dc.subject | Nanomedicina |
dc.subject.mesh | Nanomedicine |
dc.subject.mesh | Immunity, Innate |
dc.subject.mesh | Immune System |
dc.title | The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/nano11112991 |
dc.subject.decs | nanomedicina |
dc.subject.decs | inmunidad innata |
dc.subject.decs | sistema inmunológico |
dc.relation.publishversion | https://doi.org/10.3390/nano11112991 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Ernst LM] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Casals E] School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China. [Italiani P] Institute of Protein Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy. [Boraschi D] Institute of Protein Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy. Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, China. Stazione Zoologica Anton Dohrn, Napoli, Italy. [Puntes V] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Institut Català de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, Barcelona, Spain. Institució Catalana de Recerca I Estudis Avançats (ICREA), Barcelona, Spain |
dc.identifier.pmid | 34835755 |
dc.identifier.wos | 000725696500001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |