dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Winkler, Martin S. |
dc.contributor.author | Skirecki, Tomasz |
dc.contributor.author | Brunkhorst, Frank M. |
dc.contributor.author | Cajander, Sara |
dc.contributor.author | Cavaillon, Jean-Marc |
dc.contributor.author | Ferrer Roca, Ricard |
dc.date.accessioned | 2022-03-21T09:14:03Z |
dc.date.available | 2022-03-21T09:14:03Z |
dc.date.issued | 2021-04 |
dc.identifier.citation | Winkler MS, Skirecki T, Brunkhorst FM, Cajander S, Cavaillon JM, Ferrer R, et al. Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge. EBioMedicine. 2021 Apr;66:103291. |
dc.identifier.issn | 2352-3964 |
dc.identifier.uri | https://hdl.handle.net/11351/7220 |
dc.description | Animal model; COVID-19; Pre-clinical research |
dc.description.abstract | Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal. |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.relation.ispartofseries | EBioMedicine;66 |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | COVID-19 (Malaltia) - Tractament |
dc.subject | Vacunes |
dc.subject | Models animals en la investigació |
dc.subject.mesh | Coronavirus Infections |
dc.subject.mesh | /therapy |
dc.subject.mesh | Disease Models, Animal |
dc.subject.mesh | Vaccines |
dc.title | Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1016/j.ebiom.2021.103291 |
dc.subject.decs | infecciones por Coronavirus |
dc.subject.decs | /terapia |
dc.subject.decs | modelos de enfermedad en animales |
dc.subject.decs | vacunas |
dc.relation.publishversion | https://doi.org/10.1016/j.ebiom.2021.103291 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Winkler MS] Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Göttingen, Germany. [Skirecki T] Laboratory of Flow Cytometry, Centre of Postgraduate Medical Education, Warsaw, Poland. [Brunkhorst FM] Dept. of Anesthesiology and Intensive Care Medicine & Center for Sepsis Control and Care (CSCC), Jena University Hospital-Friedrich Schiller University, Jena, Germany. Center for Clinical Studies, Jena University Hospital, Jena, Germany. [Cajander S] Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Sweden. [Cavaillon JM] French National Research Agency (ANR), Paris, France. [Ferrer R] Servei de Cures Intensives i Xoc, Grup de Recerca en Disfunció Orgànica i Reanimació, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomedica En Red-Enfermedades Respiratorias, Instituto de salud Carlos III (ISCIII), Madrid, Spain |
dc.identifier.pmid | 33813139 |
dc.identifier.wos | 000647447600005 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |