dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Ip, Hill F. |
dc.contributor.author | van der Laan, Camiel M. |
dc.contributor.author | Krapohl, Eva M. L. |
dc.contributor.author | Brikell, Isabell |
dc.contributor.author | Sanchez Mora, Cristina P |
dc.contributor.author | Nolte, Ilja M. |
dc.contributor.author | Soler Artigas, Maria |
dc.contributor.author | Rovira Lorente, Paula |
dc.contributor.author | Bosch Munso, Rosa M |
dc.contributor.author | Español Martín, Gemma |
dc.contributor.author | Ramos Quiroga, José Antonio |
dc.contributor.author | Casas Brugué, Miquel |
dc.contributor.author | Ribases Haro, Marta |
dc.date.accessioned | 2022-03-23T11:54:31Z |
dc.date.available | 2022-03-23T11:54:31Z |
dc.date.issued | 2021-07-30 |
dc.identifier.citation | Ip HF, van der Laan CM, Krapohl EML, Brikell I, Sánchez-Mora C, Nolte IM, et al. Genetic association study of childhood aggression across raters, instruments, and age. Transl Psychiatry. 2021 Jul 30;11:413. |
dc.identifier.issn | 2158-3188 |
dc.identifier.uri | https://hdl.handle.net/11351/7250 |
dc.description | Genomics; Human behaviour |
dc.description.abstract | Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall) was 3.31% (SE = 0.0038). We found no genome-wide significant SNPs for AGGoverall. The gene-based analysis returned three significant genes: ST3GAL3 (P = 1.6E–06), PCDH7 (P = 2.0E–06), and IPO13 (P = 2.5E–06). All three genes have previously been associated with educational traits. Polygenic scores based on our GWAMA significantly predicted aggression in a holdout sample of children (variance explained = 0.44%) and in retrospectively assessed childhood aggression (variance explained = 0.20%). Genetic correlations (rg) among rater-specific assessment of AGG ranged from rg = 0.46 between self- and teacher-assessment to rg = 0.81 between mother- and teacher-assessment. We obtained moderate-to-strong rgs with selected phenotypes from multiple domains, but hardly with any of the classical biomarkers thought to be associated with AGG. Significant genetic correlations were observed with most psychiatric and psychological traits (range |rg|: 0.19–1.00), except for obsessive-compulsive disorder. Aggression had a negative genetic correlation (rg = ~−0.5) with cognitive traits and age at first birth. Aggression was strongly genetically correlated with smoking phenotypes (range |rg|: 0.46–0.60). The genetic correlations between aggression and psychiatric disorders were weaker for teacher-reported AGG than for mother- and self-reported AGG. The current GWAMA of childhood aggression provides a powerful tool to interrogate the rater-specific genetic etiology of AGG. |
dc.language.iso | eng |
dc.publisher | Springer Nature |
dc.relation.ispartofseries | Translational Psychiatry;11 |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Agressivitat en els infants |
dc.subject | Malalties mentals - Aspectes genètics |
dc.subject.mesh | Genetic Association Studies |
dc.subject.mesh | Mental Disorders |
dc.subject.mesh | Aggression |
dc.title | Genetic association study of childhood aggression across raters, instruments, and age |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1038/s41398-021-01480-x |
dc.subject.decs | estudios de asociación genética |
dc.subject.decs | trastornos mentales |
dc.subject.decs | agresión |
dc.relation.publishversion | https://doi.org/10.1038/s41398-021-01480-x |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Ip HF] Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. [van der Laan CM] Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Netherlands Institute for the Study of Crime and Law Enforcement, Amsterdam, The Netherlands. [Krapohl EML] Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK. [Brikell I] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. [Sánchez-Mora C, Soler Artigas M, Rovira P, Ribasés M] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain. Unitat de Genètica Psiquiàtrica, Grup de Recerca en Psiquiatria, Salut Mental i Addicció, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Nolte IM] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. [Bosch R] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain. Servei de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Español G] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Ramos Quiroga JA, Ribasés M] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain. Unitat de Genètica Psiquiàtrica, Grup de Recerca en Psiquiatria, Salut Mental i Addicció, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, Spain |
dc.identifier.pmid | 34330890 |
dc.identifier.wos | 000679719900001 |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/FP7/602768 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |