dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Díez, Juan J. |
dc.contributor.author | Iglesias, Pedro |
dc.contributor.author | Romero-Lluch, Ana |
dc.contributor.author | Sastre, Julia |
dc.contributor.author | Pérez Corral, Begoña |
dc.contributor.author | Zafon Llopis, Carles |
dc.contributor.author | Alcázar, Victoria |
dc.date.accessioned | 2022-04-06T12:13:43Z |
dc.date.available | 2022-04-06T12:13:43Z |
dc.date.issued | 2021-02 |
dc.identifier.citation | Díez JJ, Alcázar V, Iglesias P, Romero-Lluch A, Sastre J, Corral BP, et al. Thyroid lobectomy in patients with differentiated thyroid cancer: an analysis of the clinical outcomes in a nationwide multicenter study. Gland Surg. 2021 Feb;10(2):678–89. |
dc.identifier.issn | 2227-8575 |
dc.identifier.uri | https://hdl.handle.net/11351/7319 |
dc.description | Thyroid surgery; Lobectomy; Tumor recurrence |
dc.description.abstract | Background: Total thyroidectomy is the standard initial surgery for differentiated thyroid carcinoma (DTC), but the extent of the thyroidectomy remains controversial. Thyroid lobectomy (TL) has been widely used in eastern countries; however, its use has not been generalized in western countries, including Spain. Our aims were to analyse the clinical outcome of a multicentre nation-wide cohort of DTC patients treated by TL and to assess the proportion of patients who required completion of the thyroidectomy and who presented disease recurrence.
Methods: We retrospectively analyzed patients who underwent TL for DTC and were followed-up for ≥12 months. We collected demographic, clinical, and histopathological data. Dynamic risk stratification (DRS) was performed at 12 months and at last visit.
Results: One hundred and sixty-four patients (128 women, mean age 50.8 years, median follow-up 45.4 months) from 9 hospitals were included. There were 158 cases of papillary and 6 of follicular thyroid carcinoma (FTC). Remission of the disease (excellent response) was shown in 71.6% of the patients at 12 months and in 74.4% at the end of follow-up. At that time, there were 34 patients (20.7%) with indeterminate response, 6 (3.7%) with biochemical incomplete response, and 2 (1.2%) with structural incomplete response. Completion of the thyroidectomy was necessary in 8 patients (4.9%), but only 3 of them (1.8%) had disease recurrence.
Conclusions: These results, obtained in real clinical practice, suggest that TL is a safe operative option for selected patients with DTC and that the intensity of the treatment must be tailored according to the presurgical tumor-associated risk, in line with a personalized medicine. |
dc.language.iso | eng |
dc.publisher | AME Publishing Company |
dc.relation.ispartofseries | Gland Surgery;10(2) |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source | Scientia |
dc.subject | Tiroide - Càncer - Cirurgia |
dc.subject | Tiroïdectomia |
dc.subject | Avaluació de resultats (Assistència sanitària) |
dc.subject.mesh | Thyroid Neoplasms |
dc.subject.mesh | /surgery |
dc.subject.mesh | Thyroidectomy |
dc.subject.mesh | Treatment Outcome |
dc.title | Thyroid lobectomy in patients with differentiated thyroid cancer: an analysis of the clinical outcomes in a nationwide multicenter study |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.21037/gs-20-712 |
dc.subject.decs | neoplasias de la tiroides |
dc.subject.decs | /cirugía |
dc.subject.decs | tiroidectomía |
dc.subject.decs | resultado del tratamiento |
dc.relation.publishversion | http://dx.doi.org/10.21037/gs-20-712 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Díez JJ, Iglesias P] Department of Endocrinology, Hospital Universitario Ramón y Cajal, Madrid, Spain. Department of Endocrinology, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana, Majadahonda, Madrid, Spain. [Alcázar V] Department of Endocrinology, Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain. [Romero-Lluch A] Department of Endocrinology, Hospital Universitario Virgen del Rocío, Sevilla, Spain. [Sastre J] Department of Endocrinology, Complejo Hospitalario de Toledo, Toledo, Spain. [Corral BP] Department of Endocrinology, Complejo Asistencial Universitario de León, León, Spain. [Zafón C] Servei d’Endocrinologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain |
dc.identifier.pmid | 33708550 |
dc.identifier.wos | 000622479000017 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |