dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Lasheras Márquez, Jaime |
dc.contributor.author | Pardo Diaz, Rosario |
dc.contributor.author | Velilla Cajo, Marc |
dc.contributor.author | Poncelas Nozal, Marcos |
dc.contributor.author | Salvatella Serrallonga, Nuria |
dc.contributor.author | Villena Delgado, Josep A |
dc.contributor.author | Simó Canonge, Rafael |
dc.contributor.author | Ruiz Meana, Marisol |
dc.date.accessioned | 2022-04-11T10:26:03Z |
dc.date.available | 2022-04-11T10:26:03Z |
dc.date.issued | 2021-08 |
dc.identifier.citation | Lasheras J, Pardo R, Velilla M, Poncelas M, Salvatella N, Simó R, et al. Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality. Int J Mol Sci. 2021 Aug;22(15):8047. |
dc.identifier.issn | 1422-0067 |
dc.identifier.uri | https://hdl.handle.net/11351/7344 |
dc.description | Cardiac dysfunction; Estrogen-related receptors; Transgenic mice |
dc.description.abstract | Proper cardiac function depends on the coordinated expression of multiple gene networks related to fuel utilization and mitochondrial ATP production, heart contraction, and ion transport. Key transcriptional regulators that regulate these gene networks have been identified. Among them, estrogen-related receptors (ERRs) have emerged as crucial modulators of cardiac function by regulating cellular metabolism and contraction machinery. Consistent with this role, lack of ERRα or ERRγ results in cardiac derangements that lead to functional maladaptation in response to increased workload. Interestingly, metabolic inflexibility associated with diabetic cardiomyopathy has been recently associated with increased mitochondrial fatty acid oxidation and expression of ERRγ, suggesting that sustained expression of this nuclear receptor could result in a cardiac pathogenic outcome. Here, we describe the generation of mice with cardiac-specific overexpression of ERRγ, which die at young ages due to heart failure. ERRγ transgenic mice show signs of dilated cardiomyopathy associated with cardiomyocyte hypertrophy, increased cell death, and fibrosis. Our results suggest that ERRγ could play a role in mediating cardiac pathogenic responses. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | International Journal of Molecular Sciences;22(15) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Cor - Metabolisme |
dc.subject | Miocardi - Malalties - Metabolisme |
dc.subject.mesh | Myocytes, Cardiac |
dc.subject.mesh | Cardiomyopathy, Dilated |
dc.subject.mesh | /metabolism |
dc.title | Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/ijms22158047 |
dc.subject.decs | miocitos cardíacos |
dc.subject.decs | miocardiopatía dilatada |
dc.subject.decs | /metabolismo |
dc.relation.publishversion | https://doi.org/10.3390/ijms22158047 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Lasheras J, Pardo R, Velilla M, Salvatella N] Laboratori de Metabolisme i Obesitat, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Poncelas M, Ruiz-Meana M] Laboratori de Cardiologia Experimental, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Simó R] Unitat de Diabetis i Metabolisme, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain. [Villena JA] Laboratori de Metabolisme i Obesitat, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain |
dc.identifier.pmid | 34360813 |
dc.identifier.wos | 000681968700001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |