dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Castro Marrero, Jesus |
dc.contributor.author | Zacares, Mario |
dc.contributor.author | Almenar-Pérez, Eloy |
dc.contributor.author | Alegre Martin, José |
dc.contributor.author | Oltra, Elisa |
dc.date.accessioned | 2022-04-25T13:06:39Z |
dc.date.available | 2022-04-25T13:06:39Z |
dc.date.issued | 2021-09 |
dc.identifier.citation | Castro-Marrero J, Zacares M, Almenar-Pérez E, Alegre-Martín J, Oltra E. Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping. J Clin Med. 2021 Sep;10(18):4171. |
dc.identifier.issn | 2077-0383 |
dc.identifier.uri | https://hdl.handle.net/11351/7397 |
dc.description | Myalgic encephalomyelitis; Blood analytics; Diagnosis |
dc.description.abstract | Background: Routine blood analytics are systematically used in the clinic to diagnose disease or confirm individuals’ healthy status. For myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disease relying exclusively on clinical symptoms for its diagnosis, blood analytics only serve to rule out underlying conditions leading to exerting fatigue. However, studies evaluating complete and large blood datasets by combinatorial approaches to evidence ME/CFS condition or detect/identify case subgroups are still scarce. Methods: This study used unbiased hierarchical cluster analysis of a large cohort of 250 carefully phenotyped female ME/CFS cases toward exploring this possibility. Results: The results show three symptom-based clusters, classified as severe, moderate, and mild, presenting significant differences (p < 0.05) in five blood parameters. Unexpectedly the study also revealed high levels of circulating complement factor C1q in 107/250 (43%) of the participants, placing C1q as a key molecule to identify an ME/CFS subtype/subgroup with more apparent pain symptoms. Conclusions: The results obtained have important implications for the research of ME/CFS etiology and, most likely, for the implementation of future diagnosis methods and treatments of ME/CFS in the clinic. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Journal of Clinical Medicine;10(18) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Síndrome de fatiga crònica - Diagnòstic |
dc.subject | Epidemiologia clínica |
dc.subject.mesh | Fatigue Syndrome, Chronic |
dc.subject.mesh | /diagnosis |
dc.subject.mesh | Complement C1q |
dc.subject.mesh | Cluster Analysis |
dc.title | Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/jcm10184171 |
dc.subject.decs | síndrome de fatiga crónica |
dc.subject.decs | /diagnóstico |
dc.subject.decs | complemento C1q |
dc.subject.decs | análisis por grupos |
dc.relation.publishversion | https://doi.org/10.3390/jcm10184171 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Castro-Marrero J] Unitat de Recerca en Encefalomielitis Miàlgica/Síndrome de Fatiga Crònica, Divisió de Reumatologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Zacares M] Departamento de Ciencias Básicas y Transversales, Facultad de Veterinaria y Ciencias Experimentales, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain. [Almenar-Pérez E] Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain. [Alegre-Martín J] Unitat de Recerca en Encefalomielitis Miàlgica/Síndrome de Fatiga Crònica, Divisió de Reumatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Oltra E] Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain. Department of Pathology, School of Health Sciences, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain |
dc.identifier.pmid | 34575280 |
dc.identifier.wos | 000699521900001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |