dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Giralt Buch, Irina |
dc.contributor.author | Gallo, Gabriel Osvaldo |
dc.contributor.author | Zarzosa Martinez, Patricia |
dc.contributor.author | Pons Barcons, Guillem |
dc.contributor.author | Magdaleno Cazon, Ainara |
dc.contributor.author | Segura Ginard, Miguel |
dc.contributor.author | Sánchez de Toledo Codina, Josep |
dc.contributor.author | Moreno Martín-Retortillo, Lucas |
dc.contributor.author | Gallego Melcón, Soledad |
dc.contributor.author | Roma Castanyer, Josep |
dc.contributor.author | Navarro Barea, Natalia |
dc.date.accessioned | 2022-05-02T12:23:53Z |
dc.date.available | 2022-05-02T12:23:53Z |
dc.date.issued | 2021-08 |
dc.identifier.citation | Giralt I, Gallo-Oller G, Navarro N, Zarzosa P, Pons G, Magdaleno A, et al. Dickkopf Proteins and Their Role in Cancer: A Family of Wnt Antagonists with a Dual Role. Pharmaceuticals. 2021 Aug;14(8):810. |
dc.identifier.issn | 1424-8247 |
dc.identifier.uri | https://hdl.handle.net/11351/7425 |
dc.description | Dickkopf; Wnt antagonists; Wnt signaling |
dc.description.abstract | The Wnt signaling pathway regulates crucial aspects such as cell fate determination, cell polarity and organogenesis during embryonic development. Wnt pathway deregulation is a hallmark of several cancers such as lung, gastric and liver cancer, and has been reported to be altered in others. Despite the general agreement reached by the scientific community on the oncogenic potential of the central components of the pathway, the role of the antagonist proteins remains less clear. Deregulation of the pathway may be caused by overexpression or downregulation of a wide range of antagonist proteins. Although there is growing information related to function and regulation of Dickkopf (DKK) proteins, their pharmacological potential as cancer therapeutics still has not been fully developed. This review provides an update on the role of DKK proteins in cancer and possible potential as therapeutic targets for the treatment of cancer; available compounds in pre-clinical or clinical trials are also reviewed. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Pharmaceuticals;14(8) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Càncer - Tractament |
dc.subject | Transducció de senyal cel·lular |
dc.subject | Farmacologia molecular |
dc.subject.mesh | Neoplasms |
dc.subject.mesh | /therapy |
dc.subject.mesh | Wnt Signaling Pathway |
dc.subject.mesh | Molecular Targeted Therapy |
dc.title | Dickkopf Proteins and Their Role in Cancer: A Family of Wnt Antagonists with a Dual Role |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/ph14080810 |
dc.subject.decs | neoplasias |
dc.subject.decs | /terapia |
dc.subject.decs | vía de señalización Wnt |
dc.subject.decs | terapia molecular selectiva |
dc.relation.publishversion | https://doi.org/10.3390/ph14080810 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Giralt I, Gallo-Oller G, Navarro N, Zarzosa P, Pons G, Magdaleno A, Segura MF, Sánchez de Toledo J, Roma J] Laboratori de Recerca Translacional en Càncer en la Infància i l’Adolescència, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Moreno L, Gallego S] Laboratori de Recerca Translacional en Càncer en la Infància i l’Adolescència, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei d’Oncologia i Hematologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain |
dc.identifier.pmid | 34451907 |
dc.identifier.wos | 000690198100001 |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F00398 |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/PE2017-2020/PI21%2F00640 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |