dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Soriano Marcolino, Milena |
dc.contributor.author | Pires, Magda Carvalho |
dc.contributor.author | Ferreira Ramos, Lucas Emanuel |
dc.contributor.author | Tavares Silva, Rafael |
dc.contributor.author | Guimarães‑Júnior, Milton Henriques |
dc.contributor.author | Molina Romero, Israel |
dc.date.accessioned | 2022-05-02T13:12:52Z |
dc.date.available | 2022-05-02T13:12:52Z |
dc.date.issued | 2021-10-13 |
dc.identifier.citation | Molina I, Marcolino MS, Pires MC, Ramos LEF, Silva RT, Guimarães-Júnior MH, et al. Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes. Sci Rep. 2021 Oct 13;11:20289. |
dc.identifier.issn | 2045-2322 |
dc.identifier.uri | https://hdl.handle.net/11351/7452 |
dc.description | Epidemiology; Microbiology; SARS-CoV-2 |
dc.description.abstract | Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confirmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64–80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p < 0.05). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). In-hospital management, outcomes and complications were similar between the groups. In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no differences in-hospital outcomes. The lower C-reactive protein levels in CD patients require further investigation. |
dc.language.iso | eng |
dc.publisher | Nature Research |
dc.relation.ispartofseries | Scientific Reports;11 |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | COVID-19 (Malaltia) - Complicacions |
dc.subject | Chagas, Malaltia de - Complicacions |
dc.subject.mesh | Chagas Disease |
dc.subject.mesh | Coronavirus Infections |
dc.subject.mesh | /complications |
dc.subject.mesh | Hospital Mortality |
dc.title | Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1038/s41598-021-96825-3 |
dc.subject.decs | enfermedad de Chagas |
dc.subject.decs | infecciones por Coronavirus |
dc.subject.decs | /complicaciones |
dc.subject.decs | mortalidad hospitalaria |
dc.relation.publishversion | https://doi.org/10.1038/s41598-021-96825-3 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Molina I] PROSICS Barcelona. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Instituto René Rachou-FIOCRUZ Minas, 1715 Belo Horizonte, Brazil. [Marcolino MS] Department of Internal Medicine, Medical School and Telehealth Center, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil. [Pires MC, Ramos LEF, Silva RT] Department of Statistics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. [Guimarães-Júnior MH] Hospital Marcio Cunha, Ipatinga, Brazil |
dc.identifier.pmid | 34645833 |
dc.identifier.wos | 000707032500018 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |