dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Cano, Amanda |
dc.contributor.author | Fonseca Hernandez, Elena |
dc.contributor.author | Ettcheto, Miren |
dc.contributor.author | Sánchez-López, Elena |
dc.contributor.author | de Rojas, Itziar |
dc.contributor.author | Alonso-Lana, Silvia |
dc.contributor.author | Toledo Argany, Manuel |
dc.date.accessioned | 2022-05-05T12:49:38Z |
dc.date.available | 2022-05-05T12:49:38Z |
dc.date.issued | 2021-10 |
dc.identifier.citation | Cano A, Fonseca E, Ettcheto M, Sánchez-López E, Rojas I de, Alonso-Lana S, et al. Epilepsy in Neurodegenerative Diseases: Related Drugs and Molecular Pathways. Pharmaceuticals. 2021 Oct;14(10):1057. |
dc.identifier.issn | 1424-8247 |
dc.identifier.uri | https://hdl.handle.net/11351/7488 |
dc.description | Alzheimer’s disease; Huntington’s disease; Parkinson’s disease |
dc.description.abstract | Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. It is the second most prevalent neurological disease, with 50 million people affected around the world, and 30% of all epilepsies do not respond to available treatments. Currently, the main hypothesis about the molecular processes that trigger epileptic seizures and promote the neurotoxic effects that lead to cell death focuses on the exacerbation of the glutamate pathway and the massive influx of Ca2+ into neurons by different factors. However, other mechanisms have been proposed, and most of them have also been described in other neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, or multiple sclerosis. Interestingly, and mainly because of these common molecular links and the lack of effective treatments for these diseases, some antiseizure drugs have been investigated to evaluate their therapeutic potential in these pathologies. Therefore, in this review, we thoroughly investigate the common molecular pathways between epilepsy and the major neurodegenerative diseases, examine the incidence of epilepsy in these populations, and explore the use of current and innovative antiseizure drugs in the treatment of refractory epilepsy and other neurodegenerative diseases. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Pharmaceuticals;14(10) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Sistema nerviós - Degeneració - Tractament |
dc.subject | Epilèpsia |
dc.subject | Anticonvulsius - Ús terapèutic |
dc.subject.mesh | Neurodegenerative Diseases |
dc.subject.mesh | /drug therapy |
dc.subject.mesh | Epilepsy |
dc.subject.mesh | Anticonvulsants |
dc.title | Epilepsy in Neurodegenerative Diseases: Related Drugs and Molecular Pathways |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/ph14101057 |
dc.subject.decs | enfermedades neurodegenerativas |
dc.subject.decs | /farmacoterapia |
dc.subject.decs | epilepsia |
dc.subject.decs | anticonvulsivantes |
dc.relation.publishversion | https://doi.org/10.3390/ph14101057 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Cano A] Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), 08029 Barcelona, Spain. Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain. Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain. Institute of Nanoscience and Nanotechnology (IN2UB), 08028 Barcelona, Spain. [Fonseca E, Toledo M] Unitat d’Epilèpsia, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Estat Epilèptic i Convulsions Agudes, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Ettcheto M] Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain. Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain. Institute of Neurosciences (UBNeuro), University of Barcelona, 08007 Barcelona, Spain. [Sánchez-López E] Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain. Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain. Institute of Nanoscience and Nanotechnology (IN2UB), 08028 Barcelona, Spain. [de Rojas I] Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), 08029 Barcelona, Spain. Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain. [Alonso-Lana S] Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), 08029 Barcelona, Spain |
dc.identifier.pmid | 34681281 |
dc.identifier.wos | 000716873000001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |