dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Mirallas Viñas, Oriol |
dc.contributor.author | Filippi Arriaga, Maria Francesca Eugenia |
dc.contributor.author | Hernández Hernández, Irene |
dc.contributor.author | Aubanell, Anton |
dc.contributor.author | Chaachou, Anas |
dc.contributor.author | Garcia-Alvarez, Alejandro |
dc.contributor.author | Hernando Cubero, Jorge |
dc.contributor.author | Martinez Saez, Elena Antima |
dc.contributor.author | Biagetti Biagetti, Betina |
dc.contributor.author | Capdevila Castillon, Jaume |
dc.date.accessioned | 2022-06-02T08:33:20Z |
dc.date.available | 2022-06-02T08:33:20Z |
dc.date.issued | 2021-11-11 |
dc.identifier.citation | Mirallas O, Filippi-Arriaga F, Hernandez Hernandez I, Aubanell A, Chaachou A, Garcia-Alvarez A, et al. Aggressive Pituitary Macroadenoma Treated With Capecitabine and Temozolomide Chemotherapy Combination in a Patient With Nelson’s Syndrome: A Case Report. Front Endocrinol. 2021 Nov 11;12:731631. |
dc.identifier.issn | 1664-2392 |
dc.identifier.uri | https://hdl.handle.net/11351/7615 |
dc.description | Agressive pituitary tumors; Capecitabine; Temozolomide |
dc.description.abstract | Nelson’s syndrome is considered a severe side effect that can occur after a total bilateral adrenalectomy in patients with Cushing’s disease. It usually presents with clinical manifestations of an enlarging pituitary tumor including visual and cranial nerve alterations, and if not treated, can cause death through local brain compression or invasion. The first therapeutic option is surgery but in extreme cases of inaccessible or resistant aggressive pituitary tumors; the off-label use of chemotherapy with capecitabine and temozolomide can be considered. However, the use of this treatment is controversial due to adverse events, lack of complete response, and inability to predict results. We present the case of a 48-year-old man diagnosed with Nelson’s syndrome with prolonged partial response and significant clinical benefit to treatment with capecitabine and temozolomide. |
dc.language.iso | eng |
dc.publisher | Frontiers Media |
dc.relation.ispartofseries | Frontiers in Endocrinology;12 |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Adenoma - Tractament |
dc.subject | Hipòfisi - Tumors - Tractament |
dc.subject | Quimioteràpia combinada |
dc.subject.mesh | Nelson Syndrome |
dc.subject.mesh | /drug therapy |
dc.subject.mesh | Antineoplastic Combined Chemotherapy Protocols |
dc.subject.mesh | Adenoma |
dc.title | Aggressive Pituitary Macroadenoma Treated With Capecitabine and Temozolomide Chemotherapy Combination in a Patient With Nelson’s Syndrome: A Case Report |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3389/fendo.2021.731631 |
dc.subject.decs | síndrome de Nelson |
dc.subject.decs | /farmacoterapia |
dc.subject.decs | protocolos de quimioterapia antineoplásica combinada |
dc.subject.decs | adenoma |
dc.relation.publishversion | https://doi.org/10.3389/fendo.2021.731631 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Mirallas O, Garcia-Alvarez A, Hernando J, Capdevila J] Servei d’Oncologia Mèdica, Unitat de Tumors Gastrointestinals i Endocrins, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Filippi-Arriaga F] Servei de Farmacologia Clínica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Hernandez Hernandez I, Biagetti B] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Aubanell A] Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Chaachou A, Martínez-Saez E] Servei de Patologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain |
dc.identifier.pmid | 34858324 |
dc.identifier.wos | 000727887300001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |