dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Blanco Grau, Albert |
dc.contributor.author | Gabriel Medina, Pablo |
dc.contributor.author | Rodriguez-Algarra, Francisco |
dc.contributor.author | Villena Ortiz, Yolanda |
dc.contributor.author | Lopez Martinez, Rosa |
dc.contributor.author | Pons Delgado, Mònica |
dc.contributor.author | Cruz Carlos, Luz María |
dc.contributor.author | Riveiro Barciela, Maria del Mar |
dc.contributor.author | Casis Saenz, Ernesto |
dc.contributor.author | Ferrer Costa, Roser |
dc.contributor.author | Rodríguez Frias, Francisco |
dc.contributor.author | Rando Segura, Ariadna |
dc.contributor.author | Buti Ferret, Maria |
dc.contributor.author | Augustin Recio, Salvador |
dc.date.accessioned | 2022-06-15T12:49:34Z |
dc.date.available | 2022-06-15T12:49:34Z |
dc.date.issued | 2021-12 |
dc.identifier.citation | Blanco-Grau A, Gabriel-Medina P, Rodriguez-Algarra F, Villena Y, Lopez-Martínez R, Augustín S, et al. Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting. Diagnostics. 2021 Dec;11(12):2236. |
dc.identifier.issn | 2075-4418 |
dc.identifier.uri | https://hdl.handle.net/11351/7687 |
dc.description | Chronic liver disease; Fibrosis 4 score |
dc.description.abstract | Liver disease is frequently asymptomatic, challenging early identification in the primary care setting. The fibrosis 4 (FIB4) index is a liver fibrosis biomarker that is a potential alternative to liver biopsy for diagnosing and managing liver disease. This study aimed to calculate the FIB4 index for screening individuals at high risk of liver disease at the community level. This was a retrospective real-world study analyzing blood and serum test results from a central laboratory. The primary outcome was the number of individuals within each risk category for hepatic fibrosis: high risk (FIB4 ≥ 3.25) and low risk (FIB4 < 1.3). The analysis included samples from 31,753 patients, of which 18,102 were aged 40 to 75 years. In these patients, the FIB4 index had been explicitly requested in 1852 (10.2%) cases and estimated ad hoc in the rest. Of the 263 (1.5%) cases with FIB4 ≥ 3.25, the FIB4 index was requested in 46 (17.5%), and 52 (19.8%) showed evidence of liver fibrosis in their medical records, while the rest did not report any data regarding liver fibrosis. FIB4 is a simple score that can play a role as a “red flag” for early identification of patients at high risk of advanced liver fibrosis and their referral to specialized care. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartofseries | Diagnostics;11(12) |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Cirrosi hepàtica - Diagnòstic |
dc.subject | Sang - Anàlisi |
dc.subject | Marcadors bioquímics |
dc.subject.mesh | Liver Cirrhosis |
dc.subject.mesh | /diagnosis |
dc.subject.mesh | Predictive Value of Tests |
dc.title | Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.3390/diagnostics11122236 |
dc.subject.decs | cirrosis hepática |
dc.subject.decs | /diagnóstico |
dc.subject.decs | valor predictivo de las pruebas |
dc.relation.publishversion | https://doi.org/10.3390/diagnostics11122236 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Blanco-Grau A, Gabriel-Medina P, Villena Y] Servei de Bioquímica Clínica, Laboratoris Clínics, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Bioquímica Clínica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Rodriguez-Algarra F] Blizard Institute, Barts and The London School of Medicine and Dentistry, London E1 2AT, UK. [Lopez-Martínez R, Cruz LM, Casis E, Ferrer-Costa R] Servei de Bioquímica Clínica, Laboratoris Clínics, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Augustín S, Pons M] Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Rando-Segura A] Servei de Microbiologia, Laboratoris Clínics, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Riveiro M, Buti M] Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029 Madrid, Spain. Escola de Medicina i Ciències, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Rodriguez-Frias F] Servei de Bioquímica Clínica, Laboratoris Clínics, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Bioquímica Clínica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029 Madrid, Spain. Escola de Medicina i Ciències, Universitat Autònoma de Barcelona, Bellaterra, Spain |
dc.identifier.pmid | 34943471 |
dc.identifier.wos | 000736565200001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |