dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Morfouace, Marie |
dc.contributor.author | Novello, S. |
dc.contributor.author | Stevovic, A. |
dc.contributor.author | Dooms, C. |
dc.contributor.author | Janzic, Urska |
dc.contributor.author | Felip Font, Enriqueta |
dc.contributor.author | Berghmans, Thierry |
dc.date.accessioned | 2022-09-06T12:32:13Z |
dc.date.available | 2022-09-06T12:32:13Z |
dc.date.issued | 2022-05-18 |
dc.identifier.citation | Morfouace M, Novello S, Stevovic A, Dooms C, Janžič U, Berghmans T, et al. Results of screening in early and advanced thoracic malignancies in the EORTC pan-European SPECTAlung platform. Sci Rep. 2022 May 18;12:8342. |
dc.identifier.issn | 2045-2322 |
dc.identifier.uri | https://hdl.handle.net/11351/8038 |
dc.description | Cancer screening; Non-small-cell lung cancer |
dc.description.abstract | Access to a comprehensive molecular alteration screening is patchy in Europe and quality of the molecular analysis varies. SPECTAlung was created in 2015 as a pan-European screening platform for patients with thoracic malignancies. Here we report the results of almost 4 years of prospective molecular screening of patients with thoracic malignancies, in terms of quality of the program and molecular alterations identified. Patients with thoracic malignancies at any stage of disease were recruited in SPECTAlung, from June 2015 to May 2019, in 7 different countries. Molecular tumour boards were organised monthly to discuss patients’ molecular and clinical profile and possible biomarker-driven treatments, including clinical trial options. FFPE material was collected and analysed for 576 patients with diagnosis of pleural, lung, or thymic malignancies. Ultimately, 539 patients were eligible (93.6%) and 528 patients were assessable (91.7%). The turn-around time for report generation and molecular tumour board was 214 days (median). Targetable molecular alterations were observed in almost 20% of cases, but treatment adaptation was low (3% of patients). SPECTAlung showed the feasibility of a pan-European screening platform. One fifth of the patients had a targetable molecular alteration. Some operational issues were discovered and adapted to improve efficiency. |
dc.language.iso | eng |
dc.publisher | Nature Portfolio |
dc.relation.ispartofseries | Scientific Reports;12 |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Tòrax - Càncer - Diagnòstic |
dc.subject | Diagnòstic molecular |
dc.subject | Cribatge (Medicina) |
dc.subject.mesh | Thoracic Neoplasms |
dc.subject.mesh | /diagnosis |
dc.subject.mesh | Molecular Diagnostic Techniques |
dc.subject.mesh | Diagnostic Screening Programs |
dc.title | Results of screening in early and advanced thoracic malignancies in the EORTC pan-European SPECTAlung platform |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1038/s41598-022-12056-0 |
dc.subject.decs | neoplasias torácicas |
dc.subject.decs | /diagnóstico |
dc.subject.decs | técnicas de diagnóstico molecular |
dc.subject.decs | programas de cribado diagnóstico |
dc.relation.publishversion | https://doi.org/10.1038/s41598-022-12056-0 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Morfouace M, Stevovic A] EORTC HQ, 1200 Brussels, Belgium. [Novello S] Department of Oncology, University of Turin, AOU San Luigi, Orbassano (TO), Italy. [Dooms C] Department of Respiratory Diseases and Respiratory Oncology Unit, University Hospitals KU Leuven, Leuven, Belgium. [Janžič U] Department of Medical Oncology, University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik, Slovenia. [Berghmans T] Thoracic Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. [Felip E] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain |
dc.identifier.pmid | 35585228 |
dc.identifier.wos | 000797636300010 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |