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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBradbury Lobato, Melissa
dc.contributor.authorBorràs, Eva
dc.contributor.authorCastellví Vives, Josep
dc.contributor.authorMendez Fernández, Olga
dc.contributor.authorSánchez Iglesias, José Luis
dc.contributor.authorPerez Benavente, Maria Asuncion
dc.contributor.authorGil Moreno, Antonio
dc.contributor.authorSabidó, Eduard
dc.contributor.authorSantamaria Margalef, Anna
dc.date.accessioned2022-09-07T11:29:36Z
dc.date.available2022-09-07T11:29:36Z
dc.date.issued2022-03-15
dc.identifier.citationBradbury M, Borràs E, Castellví J, Méndez O, Sánchez-Iglesias JL, Pérez-Benavente A, et al. BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling. Sci Rep. 2022 Mar 15;12:4445.
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11351/8045
dc.descriptionCàncer d'ovaris; Proteòmica
dc.description.sponsorshipThis work was supported by the PhD4MD collaborative research program between the Vall d’Hebron Research Institute (VHIR) and the Centre for Genomic Regulation (CRG). The CRG/UPF Proteomics Unit is part of the Spanish Infrastructure for Omics Technologies (ICTS OmicsTech) and it is a member of the ProteoRed PRB3 consortium which is supported by grant PT17/0019 of the PE I+D+i 2013-2016 from the Instituto de Salud Carlos III (ISCIII) and ERDF. We acknowledge support from the Spanish Ministry of Science, Innovation and Universities, (CTQ2016-80364-P and “Centro de Excelencia Severo Ochoa 2013-2017”, SEV-2012-0208), and “Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya” (2017SGR595 and 2017SGR1661). This project has also received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 823839 (EPIC-XS). It has also been supported by grants from the Instituto Carlos III (PI15/00238, PI18/01017, PI21/00977), the Miguel Servet Program (CP13/00158 and CPII18/00027) and the Ministerio de Economía y Competitividad y Fondos FEDER (RTC-2015-3821-1). The authors are grateful to the team members of the Proteomics Unit at the Centre for Genomic Regulation, the Biomedical Research Group in Gynecology at the Vall d’Hebron Institute, the Gynecological Oncology Unit at the Vall d’Hebron Hospital and the Biomedical Research Group in Urology at the Vall d’Hebron Institute for their assistance.
dc.language.isoeng
dc.publisherNature Portfolio
dc.relation.ispartofseriesScientific Reports;12
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectOvaris - Càncer
dc.subjectMutació (Biologia)
dc.subjectADN - Reparació
dc.subject.meshOvarian Neoplasms
dc.subject.meshMutation
dc.subject.meshDNA Repair
dc.titleBRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41598-022-08461-0
dc.subject.decsneoplasias ováricas
dc.subject.decsmutación
dc.subject.decsreparación del ADN
dc.relation.publishversionhttps://doi.org/10.1038/s41598-022-08461-0
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Bradbury M] Proteomics Unit, Centre de Regulació Genòmica, Barcelona Institute of Science and Technology (BIST), 08003 Barcelona, Spain. Universitat Pompeu Fabra, 08003 Barcelona, Spain. Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Ginecologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Borràs E, Sabidó E] Proteomics Unit, Centre de Regulació Genòmica, Barcelona Institute of Science and Technology (BIST), 08003 Barcelona, Spain. Universitat Pompeu Fabra, 08003 Barcelona, Spain. [Castellví J] Servei de Patologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Méndez O] Laboratori de Cicle Cel•lular i Càncer, Grup de Recerca Biomèdica en Urologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sánchez-Iglesias JL, Pérez-Benavente A] Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Ginecologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Gil-Moreno A] Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Ginecologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain. [Santamaria A] Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Laboratori de Cicle Cel•lular i Càncer, Grup de Recerca Biomèdica en Urologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.identifier.pmid35292711
dc.identifier.wos000769466200020
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/823839
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F01017
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/PI21%2F00977
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/CP13%2F00158
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/CPII18%2F00027
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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