dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Callejo, Angela |
dc.contributor.author | Molina, Maria del Mar |
dc.contributor.author | Dinarès Fernández, Mª Carme |
dc.contributor.author | Hernandez Losa, Javier |
dc.contributor.author | Planas Ribas, Bibiana |
dc.contributor.author | Garcia Perez, Jorge Nestor |
dc.contributor.author | Curran Fàbregas, Adria |
dc.contributor.author | Navarro Mercadé, Jordi |
dc.contributor.author | Suanzes Diez, Paula |
dc.contributor.author | Falcó Ferrer, Vicenç |
dc.contributor.author | Burgos Cibrian, Joaquin |
dc.date.accessioned | 2022-09-09T14:44:48Z |
dc.date.available | 2022-09-09T14:44:48Z |
dc.date.issued | 2022-08-01 |
dc.identifier.citation | Callejo A, Del Mar Molina M, Dinares MC, Hernández-Losa J, Planas B, Garcia J, et al. Exploratory study of an oral screening dysplasia program for HIV-infected men who have sex with men. AIDS. 2022 Aug 1;36(10):1383–91. |
dc.identifier.issn | 1473-5571 |
dc.identifier.uri | https://hdl.handle.net/11351/8130 |
dc.description | Dysplasia; Screening; HIV-infected |
dc.description.abstract | Background:
HIV-infected men who have sex with men (MSM) are at high risk to develop human papilloma virus (HPV)-related oropharyngeal cancer. The aim of our study was to assess the usefulness of a pilot oral dysplasia screening program and its correlation with an anal dysplasia screening program.
Methods:
This was a prospective study with HIV-infected MSM. Oral and anal screenings were performed based on HPV determination, liquid cytology, direct and microscopy oral examinations, high-resolution anoscopy and biopsies, if necessary.
Results:
A total of 103 patients were included. The mean age of the patients was 44.6 years, 55.3% were smokers, and 57.3% had a history of previous anal high-grade squamous intraepithelial lesions (HSILs). The prevalence of oral HPV infections was 14% (9% HPV-high risk), the prevalence of abnormal cytology was 25.2%, and in 4.8% of the patients, oral examinations showed suspicious HSILs. Oral microscopy did not detect additional lesions that visual inspection. Five oral biopsies were performed and the results were normal. No risk factors for oral HPV infections were identified. The prevalence of anal HPV infections was 88.3% (76.7% HPV-high risk), 52.9% of the patients had altered cytology, and in 45.6% anoscopy showed changes suggestive of HSILs. Seventy-two anal biopsies were performed, detecting 25 cases of HSILs (24.3%).
A poor correlation was observed between oral and anal HPV infections (κ = 0.037).
Conclusions:
The prevalence of oral HPV infections, abnormal cytology and lesions in HIV-infected MSM was low, and their correlation with anal HPV-related lesions was slight. These results confirm the current barriers to oral dysplasia screening techniques. |
dc.language.iso | eng |
dc.publisher | Wolters Kluwer Health |
dc.relation.ispartofseries | AIDS;36(10) |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source | Scientia |
dc.subject | Anus - Malalties - Epidemiologia |
dc.subject | Infeccions per VIH - Epidemiologia |
dc.subject | Papil·lomavirus |
dc.subject.mesh | HIV Infections |
dc.subject.mesh | Papillomavirus Infections |
dc.subject.mesh | Anus Neoplasms |
dc.title | Exploratory study of an oral screening dysplasia program for HIV-infected men who have sex with men |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1097/QAD.0000000000003287 |
dc.subject.decs | infecciones por VIH |
dc.subject.decs | infecciones por Papillomavirus |
dc.subject.decs | neoplasias del ano |
dc.relation.publishversion | http://dx.doi.org/10.1097/QAD.0000000000003287 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Callejo A] Universitat Autònoma de Barcelona, Bellaterra, Spain. Hospital Universitari Germans Trias i Pujol, Badalona, Spain, Department of Otorhinolaryngology. [Del Mar Molina M, Planas B, Garcia J, Curran A, Navarro J, Suanzes P, Falcó V, Burgos J] Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Dinares MC, Hernández-Losa J] Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain |
dc.identifier.pmid | 35730367 |
dc.identifier.wos | 000829504400007 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |