Recommendations for the measurement of sexual steroids in clinical practice. A position statement of SEQCML/SEEN/SEEP

Casals Mercadal, Gregori; Urgell Rull, Eulàlia; Escobar-Morreale, Héctor; Argente, Jesús; Sesmilo, Gemma; Biagetti, Betina; Ferrer Costa, Roser

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Recommendations for the measurement of sexual steroids in clinical practice. A position statement of SEQCML/SEEN/SEEP, 2023 (792.6Kb)

Author

Casals Mercadal, Gregori

Urgell Rull, Eulàlia

Escobar-Morreale, Héctor

Date

2023-03-09

Permanent link

https://hdl.handle.net/11351/9940

DOI

10.1515/almed-2023-0020

ISSN

2628-491X

WOS

000948844500001

PMID

37359897

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Abstract

The proper clinical approach to a wide range of disorders relies on the availability of accurate, reproducible laboratory results for sexual steroids measured using methods with a high specificity and sensitivity. The chemiluminescent immunoassays currently available have analytical limitations with significant clinical implications. This position statement reviews the current limitations of laboratory techniques for the measurement of estradiol and testosterone and their impact on diverse clinical scenarios. A set of recommendations are provided to incorporate steroid hormone analysis by mass spectrometry in national health systems. International societies have recommended this methodology for a decade.

Keywords

Immunoassay; Sexual steroids; Testosterone

Bibliographic citation

Casals G, Ferrer Costa R, Urgell Rull E, Escobar-Morreale HF, Argente J, Sesmilo G, et al. Recommendations for the measurement of sexual steroids in clinical practice. A position statement of SEQCML/SEEN/SEEP. Adv Lab Med. 2023 Mar 9;4(1):52–60.