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dc.contributorIDIAP Jordi Gol
dc.contributor.authorLestón Vázquez, Marta
dc.contributor.authorGomez-Lumbreras, Ainhoa
dc.contributor.authorPrat Vallverdú, Oriol
dc.contributor.authorGiner-Soriano, Maria
dc.contributor.authorMorros, Rosa
dc.contributor.authorMARSAL MORA, JOSEP RAMON
dc.contributor.authorVilaplana-Carnerero, Carles
dc.contributor.authorVedia Urgell, Cristina
dc.date.accessioned2023-08-24T07:57:15Z
dc.date.available2023-08-24T07:57:15Z
dc.date.issued2023-08-22
dc.identifier.citationLestón Vázquez M, Vilaplana-Carnerero C, Gomez-Lumbreras A, Prat-Vallverdu O, Ramon Marsal J, Vedia Urgell C, Soriano, et al. Drug exposure during pregnancy in primary care: an algorithm and observational study from SIDIAP database, Catalunya, Spain. BMJ Open. 2023 Aug 22;13(8):e071335.
dc.identifier.issn2044-6055
dc.identifier.urihttps://hdl.handle.net/11351/10143
dc.descriptionClinical pharmacology; Primary care; Reproductive medicine
dc.description.abstractObjectives: To develop an algorithm to identify pregnancy episodes in women at childbearing age using SIDIAP (Information System for the Improvement of Research in Primary Care) data (Catalunya, Spain). To describe drugs dispensed during gestation. Design: Construction of an algorithm to identify all pregnancy episodes occurred from January 2011 to June 2020 in women aged 12–50. The variables used to create the algorithm include first day of last menstrual period, reasons for pregnancy termination and diagnoses registered in the primary healthcare records. Population-based cohort study including the pregnancy episodes identified by the algorithm. Setting: Catalonia, Spain. Participants: All women aged 12–50 with at least one pregnancy episode occurred during January 2011–June 2020. Interventions: No interventions performed. Primary and secondary outcome measures: Identification of pregnancy episodes through an algorithm and description of drug exposure. Results: We identified 327 865 pregnancy episodes in 250 910 people with a mean age of 31.3 years. During the study period, 83.4% of the episodes were exposed to at least one drug. The most frequent groups dispensed were iron preparations (48% of pregnancy episodes), iodine therapy (40.2%), analgesics and antipyretics (28%), penicillins (19.8%), vitamin B12 plus folic acid (19.7%) and non-steroidal anti-inflammatory drugs (NSAIDs, 15.1%). The supplements were more frequently dispensed at least twice, and the drugs for acute conditions were mainly dispensed only once during the pregnancy episode. Conclusions: We developed an algorithm to automatically identify the pregnancy periods in SIDIAP. We described prescription drugs used during pregnancy. The most used ones were supplements, analgesics, NSAID or antibiotics. SIDIAP might be an efficient database to study drug safety during pregnancy and the consequences of drug use in the offspring.
dc.language.isoeng
dc.publisherBMJ
dc.relation.ispartofseriesBMJ Open;13(8)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectFarmacologia clínica
dc.subjectEmbaràs
dc.subjectSalut reproductiva
dc.subjectMedicaments - Administració
dc.subject.meshPharmacology, Clinical
dc.subject.meshPregnancy
dc.subject.meshReproductive Health
dc.subject.meshPrescription Drugs
dc.titleDrug exposure during pregnancy in primary care: an algorithm and observational study from SIDIAP database, Catalunya, Spain
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1136/ bmjopen-2022-071335
dc.subject.decsfarmacología clínica
dc.subject.decsembarazo
dc.subject.decssalud reproductiva
dc.subject.decsmedicamentos por prescripción
dc.relation.publishversionhttps://doi.org/10.1136/bmjopen-2022-071335
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.authoraffiliation[Lestón Vázquez M] Àrea del Medicament i Servei de Farmàcia, Gerència d'Atenció Primària Barcelona Ciutat, Institut Català de la Salut (ICS), Generalitat de Catalunya, Barcelona, Spain. Universitat Autònoma de Barcelona (UAB), Bellaterra (Cerdanyola del Vallès), Spain. [Vilaplana-Carnerero C, Giner-Soriano M, Morros R] Universitat Autònoma de Barcelona (UAB), Bellaterra (Cerdanyola del Vallès), Spain. Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. [Gomez-Lumbreras A] College of Pharmacy, Department of Pharmacotherapy, University of Utah, Salt Lake City, Utah, USA. [Prat-Vallverdu O] Marketing farmacéutico & Investigación clínica, Barcelona, Spain. Former employee at IDIAPJGol, Barcelona, Spain. [Ramon Marsal J] Former employee at IDIAPJGol, Barcelona, Spain. RTI Health Solutions Barcelona, Barcelona, Spain. [Vedia Urgell C] Universitat Autònoma de Barcelona (UAB), Bellaterra (Cerdanyola del Vallès), Spain. Unitat de farmàcia, Servei d’Atenció Primària Barcelonès Nord i Maresme, Institut Català de la Salut (ICS), Generalitat de Catalunya, Badalona, Spain
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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