Mode and site of action of therapies targeting CGRP signaling

Labastida Ramírez, Alejandro; GOLLION, Cedric; Stanyer, Emily; Dapkute, Austeja; Braniste, Diana; Caronna, Edoardo

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Mode and site of action of therapies targeting CGRP signaling, 2023 (1.300Mb)

Date

2023-09-11

Author

Labastida Ramírez, Alejandro

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Abstract

Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs that antagonize the CGRPergic system. Therefore, this review focuses on summarizing the general pharmacology of the different types of treatments currently available, which target directly or indirectly the CGRP receptor or its ligand. Moreover, the latest evidence regarding the selectivity and site of action of CGRP small molecule antagonists (gepants) and monoclonal antibodies is critically discussed. Finally, the reasons behind non-responders to anti-CGRP drugs and rationale for combining and/or switching between these therapies are addressed.

Keywords

Calcitonin; Headache; Migraine

Bibliographic citation

Labastida-Ramírez A, Caronna E, Gollion C, Stanyer E, Dapkute A, Braniste D, et al. Mode and site of action of therapies targeting CGRP signaling. J Headache Pain. 2023 Sep 11;24:125.