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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorSANMARTIN SENTAÑES, RAMON
dc.contributor.authorVarela-Sende, Luisa
dc.contributor.authorJurek, Joanna
dc.contributor.authorLACASA-CAZCARRA, MARCOS
dc.contributor.authorAlegre, Jose
dc.contributor.authorCastro-Marrero, Jesus
dc.date.accessioned2024-01-08T10:43:38Z
dc.date.available2024-01-08T10:43:38Z
dc.date.issued2023-11
dc.identifier.citationLacasa M, Alegre-Martin J, Sanmartin Sentañes R, Varela-Sende L, Jurek J, Castro-Marrero J. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023 Nov;15(21):4504.
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/11351/10770
dc.descriptionBeta-glucan; Myalgic encephalomyelitis; Vitamin B6
dc.description.abstractThis research aimed to examine the potential alleviative effects of beta-glucan administration on fatigue, unrefreshing sleep, anxiety/depression symptoms and health-related quality of life in ME/CFS. A 36-week unicenter, randomized, double-blind, placebo-controlled trial was conducted in 65 ME/CFS patients, who were randomly allocated to one of two arms to receive four capsules each one of 250 mg beta-glucan, 3.75 µg vitamin D3, 1.05 mg vitamin B6, and 7.5 mg zinc (n = 35), or matching placebo including only microcrystalline cellulose as an excipient (n = 30) once daily. The findings showed that the beta-glucan supplementation significantly improved cognitive fatigue (assessed with FIS-40 scores) after the 36-week treatment compared to the baseline (p = 0.0338). Taken together, this study presents the novel finding that yeast-derived beta-glucan may alleviate cognitive fatigue symptoms in ME/CFS. Thus, it offers valuable scientific insights into the potential use of yeast beta-glucan as a nutritional supplement and/or functional food to prevent or reduce cognitive dysfunction in patients with ME/CFS. Further interventions are warranted to validate these findings and also to delve deeper into the possible immunometabolic pathomechanisms of beta-glucans in ME/CFS.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesNutrients;15(21)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectQualitat de vida
dc.subjectSuplements nutritius
dc.subjectSíndrome de fatiga crònica - Tractament
dc.subject.meshFatigue Syndrome, Chronic
dc.subject.meshDietary Supplements
dc.subject.meshQuality of Life
dc.titleYeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/nu15214504
dc.subject.decssíndrome de fatiga crónica
dc.subject.decssuplementos dietéticos
dc.subject.decscalidad de vida
dc.relation.publishversionhttps://doi.org/10.3390/nu15214504
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Lacasa M] E-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain. [Alegre-Martin J, Sanmartin Sentañes R, Jurek J, Castro-Marrero J] Unitat de Recerca d’Encefalomielitis Miàlgica/Síndrome de Fatiga Crònica, Servei de Reumatologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Varela-Sende L] Clinical Research Department, VITAE Health Innovation, Montmeló, Barcelona, Spain
dc.identifier.pmid37960157
dc.identifier.wos001103277500001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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