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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorLucas, Jane S
dc.contributor.authorGahleitner, Florian
dc.contributor.authorAmorim, Adelina
dc.contributor.authorBoon, Mieke
dc.contributor.authorBrown, Philippa
dc.contributor.authorConstant, Carolina
dc.contributor.authorMoreno Galdó, Antonio
dc.contributor.authorPolverino, Eva
dc.date.accessioned2019-02-22T11:46:36Z
dc.date.available2019-02-22T11:46:36Z
dc.date.issued2019-02-01
dc.identifier.citationLucas JS, Gahleitner F, Amorim A, Boon M, Brown P, Constant C, et al. Pulmonary exacerbations in patients with primary ciliary dyskinesia: an expert consensus definition for use in clinical trials. ERJ Open Res; 2019;5(1).
dc.identifier.issn2312-0541
dc.identifier.urihttp://hdl.handle.net/11351/3807
dc.descriptionPulmonary exacerbations; Primary ciliary dyskinesia; Definition
dc.description.abstractPulmonary exacerbations are a cause of significant morbidity in patients with primary ciliary dyskinesia (PCD) and are frequently used as an outcome measure in clinical research into chronic lung diseases. So far, there has been no consensus on the definition of pulmonary exacerbations in PCD. 30 multidisciplinary experts and patients developed a consensus definition for children and adults with PCD. Following a systematic review, the panel used a modified Delphi process with a combination of face-to-face meetings and e-surveys to develop a definition that can be used in research settings for children and adults with PCD. A pulmonary exacerbation was defined by the presence of three or more of the following seven items: 1) increased cough, 2) change in sputum volume and/or colour, 3) increased shortness of breath perceived by the patient or parent, 4) decision to start or change antibiotic treatment because of perceived pulmonary symptoms, 5) malaise, tiredness, fatigue or lethargy, 6) new or increased haemoptysis, and 7) temperature >38°C. The consensus panel proposed that the definition should be used for future clinical trials. The definition should be validated and the usability assessed during these studies.
dc.language.isoeng
dc.publisherEuropean Respiratory Society
dc.relation.ispartofseriesERJ Open Research;5(1)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectPulmons - Malalties
dc.subject.meshLung
dc.subject.mesh/physiopathology
dc.subject.meshKartagener Syndrome
dc.titlePulmonary exacerbations in patients with primary ciliary dyskinesia: an expert consensus definition for use in clinical trials
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1183/23120541.00147-2018
dc.subject.decspulmón
dc.subject.decs/fisiopatología
dc.subject.decssíndrome de Kartagener
dc.relation.publishversionhttps://openres.ersjournals.com/content/5/1/00147-2018
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Lucas JS, Gahleitner F] Primary Ciliary Dyskinesia Centre, NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. [Amorim A] Pulmonology Dept, Centro Hospitalar S. João, Porto, Portugal. Faculty of Medicine, Porto University, Porto, Portugal. [Boon M] Dept of Paediatrics, University Hospital Gasthuisberg, Leuven, Belgium. [Brown P] PCD Family Support Group, UK. [Constant C] Paediatric Pulmonology Unit, Paediatrics Dept, Centro Hospitalar Lisboa Norte, Lisbon Academic Medical Centre, Lisbon, Portugal. [Moreno-Galdó A] Servei d'al•lergologia pediàtrica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Polverino E] Vall d’Hebron Institut de Recerca, Barcelona, Spain. Servei de pneumologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
dc.identifier.pmid30723730
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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