Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome

Santamarina Pérez, Estevo; Maisterra Santos, Olga; Sueiras Gil, Maria; Sarria Estrada, Silvana Isabel; Guzmán García, Lorena Carolina; Salas Puig, Xavier; Toledo Argany, Manuel; Abraira del Fresno, Laura; Alpuente Ruiz, Alicia

View

Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome, 2019 (1.410Mb)

Author

Santamarina Pérez, Estevo

Maisterra Santos, Olga

Sueiras Gil, Maria

Sarria Estrada, Silvana Isabel

Guzmán García, Lorena Carolina

Salas Puig, Xavier

Toledo Argany, Manuel

Abraira del Fresno, Laura

Alpuente Ruiz, Alicia

Date

2019-02-07

Permanent link

https://hdl.handle.net/11351/4033

DOI

10.1016/j.ebcr.2019.01.008

ISSN

2213-3232

PMID

30834194

Show full item record

Abstract

To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER. All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). After an initial treatment with other anti-seizure drugs, PER was added in all cases (8, 16 and 12 mg) and cessation of SE was observed within the next 4-8 hours. All the cases involved a stroke-like lesion present on brain MRI. In our patients, PER was an effective option in SE associated with MELAS syndrome.

Keywords

MELAS; Perampanel; Status epilepticus

Bibliographic citation

Santamarina E, Alpuente A, Maisterra O, Sueiras M, Sarria S, Guzman L, et al. Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome. Epilepsy Behav Case Report. 2019;11:92–5.