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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorRodríguez-Otero, Paula
dc.contributor.authorMateos, María-Victoria
dc.contributor.authorMartinez-Lopez, Joaquin
dc.contributor.authorHernández, Miguel-Teodoro
dc.contributor.authorOcio, Enrique M
dc.contributor.authorRosiñol, Laura
dc.contributor.authorGironella Mesa, Mercedes
dc.date.accessioned2019-05-07T11:40:07Z
dc.date.available2019-05-07T11:40:07Z
dc.date.issued2019-03-18
dc.identifier.citationRodríguez-Otero P, Mateos MV, Martínez-López J, Hernández M-T, Ocio EM, Rosiñol L, et al. Predicting long-term disease control in transplant-ineligible patients with multiple myeloma: impact of an MGUS-like signature. Blood Cancer J. 2019 ;9(4):36.
dc.identifier.issn2044-5385
dc.identifier.urihttp://hdl.handle.net/11351/4062
dc.descriptionDisease control; Multiple myeloma; Biomarkers
dc.description.abstractDisease control at 5 years would be a desirable endpoint for elderly multiple myeloma (MM) patients, but biomarkers predicting this are not defined. Therefore, to gain further insights in this endpoint, a population of 498 newly diagnosed transplant-ineligible patients enrolled in two Spanish trials (GEM2005MAS65 and GEM2010MAS65), has been analyzed. Among the 435 patients included in this post-hoc study, 18.6% remained alive and progression free after 5 years of treatment initiation. In these patients, overall survival (OS) rate at 10 years was 60.8% as compared with 11.8% for those progressing within the first 5 years. Hemoglobin (Hb) ≥ 12 g/dl (OR 2.74, p = 0.001) and MGUS-like profile (OR 4.18, p = 0.005) were the two baseline variables associated with long-term disease-free survival. Upon including depth of response (and MRD), Hb ≥ 12 g/dl (OR 2.27) and MGUS-like signature (OR 7.48) retained their predictive value along with MRD negativity (OR 5.18). This study shows that despite the use of novel agents, the probability of disease control at 5 years is still restricted to a small fraction (18.6%) of elderly MM patients. Since this endpoint is associated with higher rates of OS, this study provides important information about diagnostic and post-treatment biomarkers helpful in predicting the likelihood of disease control at 5 years.
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.ispartofseriesBlood Cancer Journal;9(4)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectMieloma múltiple - Prognosi
dc.subjectMarcadors bioquímics
dc.subjectPersones grans
dc.subject.meshMultiple Myeloma
dc.subject.mesh/prevention & control
dc.subject.meshBiomarkers
dc.subject.meshAged
dc.titlePredicting long-term disease control in transplant-ineligible patients with multiple myeloma: impact of an MGUS-like signature
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41408-019-0176-x
dc.subject.decsmieloma múltiple
dc.subject.decs/prevención & control
dc.subject.decsbiomarcadores
dc.subject.decsanciano
dc.relation.publishversionhttps://www.nature.com/articles/s41408-019-0176-x
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Rodríguez-Otero P] Clínica Universidad de Navarra, Pamplona, Spain. [Mateos MV, Ocio EM] Complejo Asistencial Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain. [Martínez-López J] Hospital Universitario 12 de Octubre, Instituto de Investigación 12 de Octubre, Madrid, Spain. [Hernández MT] Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. [Rosiñol L] Hospital Clinic I Provincial, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. [Gironella M] Hospital Universitari Vall d'Hebron, Barcelona, Spain.
dc.identifier.pmid30886139
dc.identifier.wosWOS:000462349100002
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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