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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorMakhani, Naila
dc.contributor.authorLebrun, Christine
dc.contributor.authorSiva, Aksel
dc.contributor.authorNarula, Sona
dc.contributor.authorWassmer, Evangeline
dc.contributor.authorBrassat, David
dc.contributor.authorTintore Subirana, Mar
dc.date.accessioned2019-05-08T10:07:31Z
dc.date.available2019-05-08T10:07:31Z
dc.date.issued2019-03-20
dc.identifier.citationMakhani N, Lebrun C, Siva A, Narula S, Wassmer E, Brassat D, et al. Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome. Mult Scler J - Exp Transl Clin. 2019; 5(1):205521731983666.
dc.identifier.issn2055-2173
dc.identifier.urihttp://hdl.handle.net/11351/4063
dc.descriptionRadiologically isolated syndrome; Children; Multiple sclerosis
dc.description.abstractBACKGROUND: Steps towards the development of diagnostic criteria are needed for children with the radiologically isolated syndrome to identify children at risk of clinical demyelination. OBJECTIVES: To evaluate the 2005 and 2016 MAGNIMS magnetic resonance imaging criteria for dissemination in space for multiple sclerosis, both alone and with oligoclonal bands in cerebrospinal fluid added, as predictors of a first clinical event consistent with central nervous system demyelination in children with radiologically isolated syndrome. METHODS: We analysed an international historical cohort of 61 children with radiologically isolated syndrome (≤18 years), defined using the 2010 magnetic resonance imaging dissemination in space criteria (Ped-RIS) who were followed longitudinally (mean 4.2 ± 4.7 years). All index scans also met the 2017 magnetic resonance imaging dissemination in space criteria. RESULTS: Diagnostic indices (95% confidence intervals) for the 2005 dissemination in space criteria, with and without oligoclonal bands, were: sensitivity 66.7% (38.4-88.2%) versus 72.7% (49.8-89.3%); specificity 83.3% (58.6-96.4%) versus 53.9% (37.2-69.9%). For the 2016 MAGNIMS dissemination in space criteria diagnostic indices were: sensitivity 76.5% (50.1-93.2%) versus 100% (84.6-100%); specificity 72.7% (49.8-89.3%) versus 25.6% (13.0-42.1%). CONCLUSIONS: Oligoclonal bands increased the specificity of magnetic resonance imaging criteria in children with Ped-RIS. Clinicians should consider testing cerebrospinal fluid to improve diagnostic certainty. There is rationale to include cerebrospinal fluid analysis for biomarkers including oligoclonal bands in planned prospective studies to develop optimal diagnostic criteria for radiologically isolated syndrome in children
dc.language.isoeng
dc.publisherSAGE Publications
dc.relation.ispartofseriesMultiple Sclerosis Journal - Experimental, Translational and Clinical;5(1)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectEsclerosi múltiple - Imatgeria
dc.subjectImmunoglobulines
dc.subjectInfants
dc.subjectAdolescents
dc.subject.meshMultiple Sclerosis
dc.subject.mesh/diagnostic imaging
dc.subject.meshOligoclonal Bands
dc.subject.meshChild
dc.subject.meshAdolescent
dc.titleOligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1177/2055217319836664
dc.subject.decsesclerosis múltiple
dc.subject.decs/diagnóstico por imagen
dc.subject.decsbandas oligoclonales
dc.subject.decsniño
dc.subject.decsadolescente
dc.relation.publishversionhttps://journals.sagepub.com/doi/10.1177/2055217319836664
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Makhani N] Department of Pediatrics, Yale University School of Medicine, USA. Department of Neurology, Yale University School of Medicine, USA. [Lebrun C] CRCSEP Nice Hopital Pasteur, Nice, France. [Siva A] University of Istanbul, Istanbul, Turkey. Cerrahpasa School of Medicine, Istanbul, Turkey. [Narula S] Children's Hospital of Philadelphia, Philadelphia, USA. University of Pennsylvania, Philadelphia, USA. [Wassmer E] Department of Neurology, The Birmingham Children's Hospital NHS Trust, Birmingham, UK. [Brassat D] Centre Hospitalo Universitaire Purpan, Toulouse, France. [Tintoré M] Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain.
dc.identifier.pmid30915227
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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