| dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
| dc.contributor.author | Figueras-Roca, Marc |
| dc.contributor.author | Sala-Puigdollers, Anna |
| dc.contributor.author | Alba-Linero, Carmen |
| dc.contributor.author | Esquinas López, Cristina |
| dc.contributor.author | Alforja, Socorro |
| dc.contributor.author | Zarranz-Ventura, Javier |
| dc.date.accessioned | 2019-05-28T07:02:00Z |
| dc.date.available | 2019-05-28T07:02:00Z |
| dc.date.issued | 2019-04-01 |
| dc.identifier.citation | Figueras-Roca M, Sala-Puigdollers A, Zarranz-Ventura J, Alba-Linero C, Alforja S, Esquinas C, et al. Anatomic Response to Intravitreal Dexamethasone Implant and Baseline Aqueous Humor Cytokine Levels in Diabetic Macular Edema. Invest Opthalmol Vis Sci. 2019;60(5):1336. |
| dc.identifier.issn | 0146-0404 |
| dc.identifier.uri | https://hdl.handle.net/11351/4087 |
| dc.description | Dexamethasone; Cytokine; Macular Edema |
| dc.description.abstract | PURPOSE:
To determine whether baseline cytokine aqueous humor (AH) levels are associated with diabetic macular edema (DME) anatomic response to dexamethasone intravitreal implant (DEX) injection.
METHODS:
This was a prospective cohort study of DME cases receiving DEX treatment. Seventy patients were recruited with center-involving DME with spectral-domain (SD) optical coherence tomography (OCT) detection of central macular thickness (CMT) ≥300 μm on macular cube 518 × 128-μm scan protocol (Cirrus SD-OCT). DEX injection and anterior chamber tap to obtain an AH sample were performed at the same time. Multiplex immunoassay was carried out for interleukin (IL)-1β, IL-3, IL-6, IL-8, IL-10; monocyte chemoattractant protein (MCP)-1; interferon gamma-induced protein (IP)-10; tumor necrosis factor (TNF)-α; and vascular endothelial growth factor (VEGF). A follow-up visit and OCT exam were undertaken 6 to 8 weeks afterward. The association between AH cytokine baseline levels and change in CMT and macular volume (MV) was defined as main outcome measure.
RESULTS:
Multivariate linear regression analysis showed a higher decrease in MV to be associated (Rs of 0.512) with four baseline items: higher MCP-1 (β = -0.4; P = 0.028), higher CMT (β = -0.003; P = 0.024), decreased visual acuity (β = -0.7; P = 0.040), and a diffuse retinal thickening (DRT) OCT pattern (β = -1.3; P < 0.001). Logistic regression found DRT also to be associated with higher odds of a good MV response (odds ratio, 31.96; 95% confidence interval [CI] 7.11-143.72; P < 0.001).
CONCLUSIONS:
Even though visual acuity response and anatomic effect are not always correlated in DME, we found that baseline elevated MCP-1 AH levels and DRT pattern were biomarkers that predicted a future favorable anatomic response to DEX. |
| dc.language.iso | eng |
| dc.publisher | Association for Research in Vision and Ophthalmology |
| dc.relation.ispartofseries | Investigative Ophthalmology & Visual Science;60(5) |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.source | Scientia |
| dc.subject | Edema - Tractament - Estudi de casos |
| dc.subject | Dexametasona |
| dc.subject | Citocines |
| dc.subject | Humor aquós |
| dc.subject.mesh | Macular Edema |
| dc.subject.mesh | Dexamethasone |
| dc.subject.mesh | Cytokines |
| dc.subject.mesh | Aqueous Humor |
| dc.subject.mesh | /drug effects |
| dc.title | Anatomic Response to Intravitreal Dexamethasone Implant and Baseline Aqueous Humor Cytokine Levels in Diabetic Macular Edema |
| dc.type | info:eu-repo/semantics/article |
| dc.identifier.doi | 10.1167/iovs.18-26215 |
| dc.subject.decs | edema macular |
| dc.subject.decs | dexametasona |
| dc.subject.decs | citocinas |
| dc.subject.decs | humor acuoso |
| dc.subject.decs | /efectos de los fármacos |
| dc.relation.publishversion | https://iovs.arvojournals.org/article.aspx?articleid=2730017 |
| dc.type.version | info:eu-repo/semantics/publishedVersion |
| dc.audience | Professionals |
| dc.contributor.organismes | Institut Català de la Salut |
| dc.contributor.authoraffiliation | [Figueras-Roca M, Sala-Puigdollers A, Zarranz-Ventura J, Alforja S] Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [Alba-Linero C] Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain. [Esquinas C] Servei de pneumologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. |
| dc.identifier.pmid | 30933261 |
| dc.identifier.wos | WOS:000466757300007 |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess |