Show simple item record

 
dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorEspinosa Pereiro, Juan
dc.contributor.authorSánchez Montalvá, Adrián
dc.contributor.authorSalvador Velez, Fernando M
dc.contributor.authorSao Aviles, Augusto Cesar
dc.contributor.authorSulleiro Igual, Elena
dc.contributor.authorMolina Romero, Israel
dc.date.accessioned2019-08-08T06:29:21Z
dc.date.available2019-08-08T06:29:21Z
dc.date.issued2019-05-24
dc.identifier.citationEspinosa-Pereiro J, Sánchez-Montalvá A, Salvador F, Sao-Avilés A, Sulleiro E, Molina I. A retrospective study on the influence of siblings’ relatedness in Bolivian patients with chronic Chagas disease. Parasit Vectors. 2019;12(1):260.
dc.identifier.issn1756-3305
dc.identifier.urihttp://hdl.handle.net/11351/4252
dc.descriptionBrotherhood; Cardiomyopathy; Chagas disease
dc.description.abstractBACKGROUND: Chagas disease is a protozoan infection caused by Trypanosoma cruzi. The disease has a chronic course in which 20-30% of the patients would develop progressive damage to the cardiovascular system and the gastrointestinal tube. We are still unable to predict who will develop end-organ damage but there are some acquired and genetic risk factors already known. RESULTS: We reviewed data from 833 patients with serologically confirmed Chagas disease in this retrospective study. Patients were classified as siblings or non-siblings (controls) and the results of pre-treatment blood PCR assay, end-organ damage (cardiac and/or gastrointestinal), and the presence of delayed type hypersensitivity (DTH) skin involvement in patients treated with benznidazole were analyzed. Siblings were grouped by family and we randomly generated groups of 2 or 3 persons with the remaining controls. We classified the results of each variable as concordant or discordant and compared the concordance in these results among the sibling groups with that among control groups. We identified 71 groups of siblings and randomly generated 299 groups of non-related patients. Pre-treatment blood PCR concordance was significantly higher (19%) among siblings compared to controls (P = 0.02), probably due to a higher frequency in pre-treatment positive results. No other statistically significant differences were found. CONCLUSIONS: A significant difference was found in the concordance of pre-treatment blood PCR for T. cruzi among siblings compared to non-related controls.
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofseriesParasites and Vectors;12(1)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectChagas, Malaltia de
dc.subjectSang - Anàlisi
dc.subjectReacció en cadena de la polimerasa
dc.subjectGermans i germanes - Malalties - Estudi de casos
dc.subject.meshChagas Disease
dc.subject.mesh/blood
dc.subject.meshPolymerase Chain Reaction
dc.subject.meshSiblings
dc.titleA retrospective study on the influence of siblings' relatedness in Bolivian patients with chronic Chagas disease
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1186/s13071-019-3518-4
dc.subject.decsenfermedad de Chagas
dc.subject.decs/sangre
dc.subject.decsreacción en cadena de la polimerasa
dc.subject.decshermanos
dc.relation.publishversionhttps://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-019-3518-4
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Espinosa-Pereiro J] Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Programa de Salut Internacional de l'Institut Català de la Salut (PROSICS), Barcelona, Spain. [Sánchez-Montalvá A, Salvador F, Molina I] Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Programa de Salut Internacional de l'Institut Català de la Salut (PROSICS), Barcelona, Spain. Vall d’Hebron Institut de Recerca, Barcelona, Spain. [Sao-Avilés A] Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Programa de Salut Internacional de l'Institut Català de la Salut (PROSICS), Barcelona, Spain. Unitat d'ecocardiografia i imatge cardíaca, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sulleiro E] Servei de Microbiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona Barcelona, Spain.
dc.identifier.pmid31126327
dc.identifier.wosWOS:000468877800002
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record