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The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorMattos Arruda, Leticia de
dc.contributor.authorSammut, Stephen-John
dc.contributor.authorRoss, Edith M
dc.contributor.authorBashford-Rogers, Rachael
dc.contributor.authorGreenstein, Erez
dc.contributor.authorMarkus, Havell
dc.contributor.authorMayor Ferreras, Regina Gabriela
dc.contributor.authorArias Piñeiro, Alexandra
dc.contributor.authorCiriaco Cortés, Nikaoly
dc.contributor.authorMartinez Saez, Elena Antima
dc.contributor.authorPeg Camara, Vicente
dc.contributor.authorRamon y Cajal Agüeras, Santiago
dc.contributor.authorCortés Castan, Javier
dc.contributor.authorSeoane Suarez, Joan
dc.date.accessioned2019-08-08T06:29:26Z
dc.date.available2019-08-08T06:29:26Z
dc.date.issued2019-05-28
dc.identifier.citationDe Mattos-Arruda L, Sammut S-J, Ross EM, Bashford-Rogers R, Greenstein E, Markus H, et al. The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer. Cell Rep. 2019; 27(9):2690-2708.
dc.identifier.issn2211-1247
dc.identifier.urihttps://hdl.handle.net/11351/4255
dc.descriptionTCR repertoire; Breast cancer; Clade mutations
dc.description.abstractThe detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsies from 10 patients with therapy-resistant breast cancer. The integrated genomic and immune landscapes show that metastases propagate and evolve as communities of clones, reveal their predicted neo-antigen landscapes, and show that they can accumulate HLA loss of heterozygosity (LOH). The data further identify variable tumor microenvironments and reveal, through analyses of T cell receptor repertoires, that adaptive immune responses appear to co-evolve with the metastatic genomes. These findings reveal in fine detail the landscapes of lethal metastatic breast cancer.
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesCell Reports;27(9)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectMama - Càncer - Aspectes genètics
dc.subjectMama - Càncer - Aspectes immunològics
dc.subjectMetàstasi
dc.subject.meshBreast Neoplasms
dc.subject.meshNeoplasm Metastasis
dc.subject.mesh/genetics
dc.subject.mesh/immunology
dc.titleThe Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.celrep.2019.04.098
dc.subject.decsneoplasias de la mama
dc.subject.decsmetástasis neoplásica
dc.subject.decs/genética
dc.subject.decs/inmunología
dc.relation.publishversionhttps://www.sciencedirect.com/science/article/pii/S2211124719305789?via%3Dihub
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[De Mattos-Arruda L] Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK. University of Cambridge, Cambridge, UK. Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sammut SJ, Ross EM] Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK. University of Cambridge, Cambridge, UK. [Bashford-Rogers R] Department of Medicine, University of Cambridge, Cambridge, UK. [Greenstein E] Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. [Markus H] Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, USA. Mayo Clinic Center for Individualized Medicine, Scottsdale, USA. [Mayor R, Arias A] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain. [Ciriaco N] Servei d’Anatomia Patològica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Martinez-Saez E] Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain. Servei d’Anatomia Patològica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Peg V, Ramon Y Cajal S] Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain. Servei d’Anatomia Patològica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Cortes J] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Ramon y Cajal Hospital, Madrid, Spain. [Seoane J] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
dc.identifier.pmid31141692
dc.identifier.wosWOS:000469216500015
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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