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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorCorominas, Héctor
dc.contributor.authorAlegre de Miguel, Cayetano
dc.contributor.authorNarváez, Javier
dc.contributor.authorFernández-Cid, Carlos Marras
dc.contributor.authorTorrente-Segarra, Vicenc
dc.contributor.authorGómez, Manuel Rodríguez
dc.date.accessioned2019-08-22T06:18:03Z
dc.date.available2019-08-22T06:18:03Z
dc.date.issued2019-06
dc.identifier.citationCorominas H, Alegre C, Narváez J, Fernández-Cid CM, Torrente-Segarra V, Gómez MR, et al. Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab. Medicine (Baltimore). 2019;98(26):e15947.
dc.identifier.issn0025-7974
dc.identifier.urihttp://hdl.handle.net/11351/4267
dc.descriptionRheumatoid arthritis; Fatigue; Tocilizumab
dc.description.abstractTo assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effect in fatigue and other clinical and psychological disease-related factors in patients with rheumatoid arthritis (RA) treated with TCZ.A 24-week, multicenter, prospective, observational study in patients with moderate to severe RA receiving TCZ after failure or intolerance to disease-modifying antirheumatic drugs or tumor necrosis factor-alpha was conducted.Of the 122 patients included, 85 were evaluable for effectiveness (85% female, 51.9 ± 12.5 years, disease duration 8.7 ± 7.4 years). Mean change in C-reactive protein level from baseline to week 12 was -11.2 ± 4.0 (P < .001). Mean Disease Activity Index score (DAS28) decreased from 5.5 ± 1.0 at baseline to 2.7 ± 1.3 (P < .001) at week 24. Mean change in Functional Assessment of Chronic Illness Therapy score was -5.4 ± 11.2 points at week 24. Multiple regression analysis showed that the improvement in DAS28, sleep, and depression explained 56% and 47% of fatigue variance at week 12 and 24, respectively.Tocilizumab is effective in reducing disease activity and results in a clinically significant improvement in fatigue, pain, swollen joint count, morning stiffness, sleepiness, depression, and DAS28; the last 3 were specifically identified as factors explaining fatigue variance with the use of TCZ in RA patients.
dc.language.isoeng
dc.publisherLippincott, Williams & Wilkins
dc.relation.ispartofseriesMedicine;98(26)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectFatiga
dc.subjectAnticossos monoclonals
dc.subjectArtritis reumatoide - Tractament
dc.subject.meshArthritis, Rheumatoid
dc.subject.meshFatigue
dc.subject.mesh/therapy
dc.subject.meshAntibodies, Monoclonal, Humanized
dc.subject.mesh/therapeutic use
dc.titleCorrelation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1097/MD.0000000000015947
dc.subject.decsartritis reumatoide
dc.subject.decsfatiga
dc.subject.decs/terapia
dc.subject.decsanticuerpos monoclonales humanizados
dc.subject.decs/uso terapéutico
dc.relation.publishversionhttps://journals.lww.com/md-journal/fulltext/2019/06280/Correlation_of_fatigue_with_other_disease_related.11.aspx
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Corominas H] Departament de Reumatologia, Hospital Sant Joan Despí Moises Broggi, Sant Joan Despí, Spain. [Alegre C] Servei de Reumatologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Narváez J] Departament de Reumatologia, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain. [Fernández-Cid CM] Department of Rheumatology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain. [Torrente-Segarra V] Departament de Reumatologia, Hospital General de l'Hospitalet, L'Hospitalet de Llobregat, Spain. [Gómez MR] Department of Rheumatology, Complejo Hospitalario Cristal Piñor, Ourense, Spain.
dc.identifier.pmid31261500
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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